Literature DB >> 22778844

(S)-(+)-mecamylamine (TC-5214): a neuronal nicotinic receptor modulator enters phase III trials as an adjunct treatment for Major Depressive Disorder (MDD).

Craig W Lindsley.   

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Year:  2010        PMID: 22778844      PMCID: PMC3368682          DOI: 10.1021/cn100070s

Source DB:  PubMed          Journal:  ACS Chem Neurosci        ISSN: 1948-7193            Impact factor:   4.418


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  3 in total

1.  The economic burden of depression in the United States: how did it change between 1990 and 2000?

Authors:  Paul E Greenberg; Ronald C Kessler; Howard G Birnbaum; Stephanie A Leong; Sarah W Lowe; Patricia A Berglund; Patricia K Corey-Lisle
Journal:  J Clin Psychiatry       Date:  2003-12       Impact factor: 4.384

2.  The top prescription drugs of 2009 in the US: CNS therapeutics rank among highest grossing.

Authors:  Craig W Lindsley
Journal:  ACS Chem Neurosci       Date:  2010-06-16       Impact factor: 4.418

Review 3.  TC-5214 (S-(+)-mecamylamine): a neuronal nicotinic receptor modulator with antidepressant activity.

Authors:  Patrick M Lippiello; Jessica S Beaver; Gregory J Gatto; John W James; Kristen G Jordan; Vincent M Traina; Jianxun Xie; Merouane Bencherif
Journal:  CNS Neurosci Ther       Date:  2008       Impact factor: 5.243

  3 in total
  6 in total

Review 1.  Translating laboratory discovery to the clinic: from nicotine and mecamylamine to Tourette's, depression, and beyond.

Authors:  Paul R Sanberg; Cecilia Vindrola-Padros; R Douglas Shytle
Journal:  Physiol Behav       Date:  2012-07-06

Review 2.  Functional brain imaging of nicotinic effects on higher cognitive processes.

Authors:  Paul A Newhouse; Alexandra S Potter; Julie A Dumas; Christiane M Thiel
Journal:  Biochem Pharmacol       Date:  2011-06-13       Impact factor: 5.858

Review 3.  Towards new mechanisms: an update on therapeutics for treatment-resistant major depressive disorder.

Authors:  G I Papakostas; D F Ionescu
Journal:  Mol Psychiatry       Date:  2015-07-07       Impact factor: 15.992

Review 4.  Citalopram versus other anti-depressive agents for depression.

Authors:  Andrea Cipriani; Marianna Purgato; Toshi A Furukawa; Carlotta Trespidi; Giuseppe Imperadore; Alessandra Signoretti; Rachel Churchill; Norio Watanabe; Corrado Barbui
Journal:  Cochrane Database Syst Rev       Date:  2012-07-11

5.  Similar activity of mecamylamine stereoisomers in vitro and in vivo.

Authors:  Roger L Papke; Clare Stokes; Pretal Muldoon; M Imad Damaj
Journal:  Eur J Pharmacol       Date:  2013-10-23       Impact factor: 4.432

6.  Molecular interactions between mecamylamine enantiomers and the transmembrane domain of the human α4β2 nicotinic receptor.

Authors:  Vasyl Bondarenko; Katarzyna M Targowska-Duda; Krzysztof Jozwiak; Pei Tang; Hugo R Arias
Journal:  Biochemistry       Date:  2014-01-30       Impact factor: 3.162

  6 in total

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