Literature DB >> 22778343

Given financial constraints, it would be unethical to divert antiretroviral drugs from treatment to prevention.

Ruth Macklin1, Ethan Cowan.   

Abstract

Striking advances in HIV prevention have set the stage for renewed debate on setting priorities in the fight against HIV/AIDS. Two new prevention strategies--preexposure prophylaxis and treatment as prevention--use antiretroviral drugs for prevention of HIV/AIDS in addition to treating patients. The potential for success of these new prevention strategies sets up an ethical dilemma: where resources are limited and supplies of lifesaving antiretroviral medications are insufficient to treat those currently living with HIV, how should these resources be divided between treatment and prevention? This article explores several ethical principles used in formulating public health policy. Assuming that limited resources are available for spending on drugs, we conclude that it would be unethical to watch patients with treatable AIDS worsen and die, even with supportive care, so that medications for treatment can be diverted for prevention.

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Year:  2012        PMID: 22778343      PMCID: PMC3572856          DOI: 10.1377/hlthaff.2012.0071

Source DB:  PubMed          Journal:  Health Aff (Millwood)        ISSN: 0278-2715            Impact factor:   6.301


  9 in total

1.  Accountability for reasonableness.

Authors:  N Daniels
Journal:  BMJ       Date:  2000-11-25

Review 2.  HIV prevention before HAART in sub-Saharan Africa.

Authors:  Elliot Marseille; Paul B Hofmann; James G Kahn
Journal:  Lancet       Date:  2002-05-25       Impact factor: 79.321

3.  Effectiveness and safety of tenofovir gel, an antiretroviral microbicide, for the prevention of HIV infection in women.

Authors:  Quarraisha Abdool Karim; Salim S Abdool Karim; Janet A Frohlich; Anneke C Grobler; Cheryl Baxter; Leila E Mansoor; Ayesha B M Kharsany; Sengeziwe Sibeko; Koleka P Mlisana; Zaheen Omar; Tanuja N Gengiah; Silvia Maarschalk; Natasha Arulappan; Mukelisiwe Mlotshwa; Lynn Morris; Douglas Taylor
Journal:  Science       Date:  2010-07-19       Impact factor: 47.728

4.  Fair process in patient selection for antiretroviral treatment in WHO's goal of 3 by 5.

Authors:  Norman Daniels
Journal:  Lancet       Date:  2005 Jul 9-15       Impact factor: 79.321

5.  Preexposure chemoprophylaxis for HIV prevention in men who have sex with men.

Authors:  Robert M Grant; Javier R Lama; Peter L Anderson; Vanessa McMahan; Albert Y Liu; Lorena Vargas; Pedro Goicochea; Martín Casapía; Juan Vicente Guanira-Carranza; Maria E Ramirez-Cardich; Orlando Montoya-Herrera; Telmo Fernández; Valdilea G Veloso; Susan P Buchbinder; Suwat Chariyalertsak; Mauro Schechter; Linda-Gail Bekker; Kenneth H Mayer; Esper Georges Kallás; K Rivet Amico; Kathleen Mulligan; Lane R Bushman; Robert J Hance; Carmela Ganoza; Patricia Defechereux; Brian Postle; Furong Wang; J Jeff McConnell; Jia-Hua Zheng; Jeanny Lee; James F Rooney; Howard S Jaffe; Ana I Martinez; David N Burns; David V Glidden
Journal:  N Engl J Med       Date:  2010-11-23       Impact factor: 91.245

6.  Ethical challenges in long-term funding for HIV/AIDS.

Authors:  Dan W Brock; Daniel Wikler
Journal:  Health Aff (Millwood)       Date:  2009 Nov-Dec       Impact factor: 6.301

7.  Prevention of HIV-1 infection with early antiretroviral therapy.

Authors:  Myron S Cohen; Ying Q Chen; Marybeth McCauley; Theresa Gamble; Mina C Hosseinipour; Nagalingeswaran Kumarasamy; James G Hakim; Johnstone Kumwenda; Beatriz Grinsztejn; Jose H S Pilotto; Sheela V Godbole; Sanjay Mehendale; Suwat Chariyalertsak; Breno R Santos; Kenneth H Mayer; Irving F Hoffman; Susan H Eshleman; Estelle Piwowar-Manning; Lei Wang; Joseph Makhema; Lisa A Mills; Guy de Bruyn; Ian Sanne; Joseph Eron; Joel Gallant; Diane Havlir; Susan Swindells; Heather Ribaudo; Vanessa Elharrar; David Burns; Taha E Taha; Karin Nielsen-Saines; David Celentano; Max Essex; Thomas R Fleming
Journal:  N Engl J Med       Date:  2011-07-18       Impact factor: 91.245

8.  Vaccination with ALVAC and AIDSVAX to prevent HIV-1 infection in Thailand.

Authors:  Supachai Rerks-Ngarm; Punnee Pitisuttithum; Sorachai Nitayaphan; Jaranit Kaewkungwal; Joseph Chiu; Robert Paris; Nakorn Premsri; Chawetsan Namwat; Mark de Souza; Elizabeth Adams; Michael Benenson; Sanjay Gurunathan; Jim Tartaglia; John G McNeil; Donald P Francis; Donald Stablein; Deborah L Birx; Supamit Chunsuttiwat; Chirasak Khamboonruang; Prasert Thongcharoen; Merlin L Robb; Nelson L Michael; Prayura Kunasol; Jerome H Kim
Journal:  N Engl J Med       Date:  2009-10-20       Impact factor: 91.245

9.  Separate spheres and indirect benefits.

Authors:  Dan W Brock
Journal:  Cost Eff Resour Alloc       Date:  2003-02-26
  9 in total
  13 in total

1.  Bioethical challenges with HIV treatment as prevention.

Authors:  Jeremy Sugarman
Journal:  Clin Infect Dis       Date:  2014-07       Impact factor: 9.079

2.  When rationing becomes inevitable in a pandemic: A discussion on the ethical considerations from a public health perspective.

Authors:  Yuk-Chiu Yip; Ka-Huen Yip; Wai-King Tsui
Journal:  Public Health Pract (Oxf)       Date:  2022-07-08

3.  Efficient single tobamoviral vector-based bioproduction of broadly neutralizing anti-HIV-1 monoclonal antibody VRC01 in Nicotiana benthamiana plants and utility of VRC01 in combination microbicides.

Authors:  Krystal Teasley Hamorsky; Tiffany W Grooms-Williams; Adam S Husk; Lauren J Bennett; Kenneth E Palmer; Nobuyuki Matoba
Journal:  Antimicrob Agents Chemother       Date:  2013-02-12       Impact factor: 5.191

4.  Ethics and pre-exposure prophylaxis for HIV infection.

Authors:  Jeremy Sugarman; Kenneth H Mayer
Journal:  J Acquir Immune Defic Syndr       Date:  2013-07       Impact factor: 3.731

5.  Ethical use of antiretroviral resources for HIV prevention in resource poor settings.

Authors:  Stuart Rennie
Journal:  Dev World Bioeth       Date:  2013-05-31       Impact factor: 2.294

6.  Social justice and HIV vaccine research in the age of pre-exposure prophylaxis and treatment as prevention.

Authors:  Theodore C Bailey; Jeremy Sugarman
Journal:  Curr HIV Res       Date:  2013-09       Impact factor: 1.581

7.  Optimal Individualized Treatments in Resource-Limited Settings.

Authors:  Alexander R Luedtke; Mark J van der Laan
Journal:  Int J Biostat       Date:  2016-05-01       Impact factor: 0.968

8.  PrEP Implementation Science: State-of-the-Art and Research Agenda.

Authors:  Carlos F Cáceres; Kenneth H Mayer; Rachel Baggaley; Kevin R O'Reilly
Journal:  J Int AIDS Soc       Date:  2015-07-20       Impact factor: 5.396

9.  Translating PrEP effectiveness into public health impact: key considerations for decision-makers on cost-effectiveness, price, regulatory issues, distributive justice and advocacy for access.

Authors:  Catherine Hankins; Ruth Macklin; Mitchell Warren
Journal:  J Int AIDS Soc       Date:  2015-07-20       Impact factor: 5.396

10.  Partner notification in the context of HIV: an interest-analysis.

Authors:  Amos K Laar; Debra A DeBruin; Susan Craddock
Journal:  AIDS Res Ther       Date:  2015-05-05       Impact factor: 2.250

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