Literature DB >> 22778284

Management of tibial non-union with tricalcium phosphate and BMP 7.

Jonathan Cubitt1, Andrew McAndrew.   

Abstract

We present the case of a 30-year-old woman who was referred with an established tibial non-union with a bone defect following a spiral fracture of the tibia. Initial attempts at union with intramedullary fixation and then autograft were unsuccessful. We achieved union by debriding the fibrous tissue and packing the defect with Bone Morphogenetic Protein 7 (Osigraft, Stryker, UK) and a tricalcium phosphate bone void filler (Calstrux, Stryker, UK). We did not use any additional surgical fixation and the patient was supported in an aircast boot.

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Year:  2010        PMID: 22778284      PMCID: PMC3027462          DOI: 10.1136/bcr.02.2010.2777

Source DB:  PubMed          Journal:  BMJ Case Rep        ISSN: 1757-790X


  11 in total

Review 1.  Bone-grafting and bone-graft substitutes.

Authors:  Christopher G Finkemeier
Journal:  J Bone Joint Surg Am       Date:  2002-03       Impact factor: 5.284

2.  OP-1 clinical studies.

Authors:  G E Friedlaender
Journal:  J Bone Joint Surg Am       Date:  2001       Impact factor: 5.284

3.  Composite implant of native bovine bone morphogenetic protein (BMP) and biocoral in the treatment of scaphoid nonunions--a preliminary study.

Authors:  S Kujala; T Raatikainen; J Ryhänen; O Kaarela; P Jalovaara
Journal:  Scand J Surg       Date:  2002       Impact factor: 2.360

Review 4.  Current and future clinical applications of bone morphogenetic proteins in orthopaedic trauma surgery.

Authors:  Gavin B Bishop; Thomas A Einhorn
Journal:  Int Orthop       Date:  2007-08-01       Impact factor: 3.075

Review 5.  Tissue engineering of bone: material and matrix considerations.

Authors:  Yusuf Khan; Michael J Yaszemski; Antonios G Mikos; Cato T Laurencin
Journal:  J Bone Joint Surg Am       Date:  2008-02       Impact factor: 5.284

6.  Recombinant human BMP-2 and allograft compared with autogenous bone graft for reconstruction of diaphyseal tibial fractures with cortical defects. A randomized, controlled trial.

Authors:  Alan L Jones; Robert W Bucholz; Michael J Bosse; Sohail K Mirza; Thomas R Lyon; Lawrence X Webb; Andrew N Pollak; Jane Davis Golden; Alexandre Valentin-Opran
Journal:  J Bone Joint Surg Am       Date:  2006-07       Impact factor: 5.284

7.  Repair of alveolar clefts with recombinant human bone morphogenetic protein (rhBMP-2) in patients with clefts.

Authors:  Martin Chin; Theodore Ng; William K Tom; Michael Carstens
Journal:  J Craniofac Surg       Date:  2005-09       Impact factor: 1.046

Review 8.  Clinical effectiveness and cost-effectiveness of bone morphogenetic proteins in the non-healing of fractures and spinal fusion: a systematic review.

Authors:  K R Garrison; S Donell; J Ryder; I Shemilt; M Mugford; I Harvey; F Song
Journal:  Health Technol Assess       Date:  2007-08       Impact factor: 4.014

9.  Repair of a resistant tibial non-union with a recombinant bone morphogenetic protein-7 (rh-BMP-7).

Authors:  M Pecina; M Haspl; M Jelic; S Vukicevic
Journal:  Int Orthop       Date:  2003-06-17       Impact factor: 3.075

10.  [Treatment of traumatic bone defect with graft material of allogenic cancellous combined with autologous red marrow].

Authors:  Zhigang Kong; Dehu Tian; Haiquan Yu; Wenling Feng; Changcheng Liu
Journal:  Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi       Date:  2008-10
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  1 in total

1.  In vivo tricalcium phosphate, bone morphogenetic protein and autologous bone marrow biomechanical enhancement in vertebral fractures in a porcine model.

Authors:  Elena Manrique; David Chaparro; Juan Luis Cebrián; Luis López-Durán
Journal:  Int Orthop       Date:  2014-06-07       Impact factor: 3.075

  1 in total

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