| Literature DB >> 22777593 |
W van der Hoek1, C C H Wielders, B Schimmer, M C A Wegdam-Blans, J Meekelenkamp, H L Zaaijer, P M Schneeberger.
Abstract
The presence of a high phase I IgG antibody titre may indicate chronic infection and a risk for the transmission of Coxiella burnetii through blood transfusion. The outbreak of Q fever in the Netherlands allowed for the comparison of an enzyme immunoassay (EIA) with the reference immunofluorescence assay (IFA) in a large group of individuals one year after acute Q fever. EIA is 100 % sensitive in detecting high (≥1:1,024) phase I IgG antibody titres. The cost of screening with EIA and confirming all EIA-positive results with IFA is much lower than screening all donations with IFA. This should be taken into account in cost-effectiveness analyses of screening programmes.Entities:
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Year: 2012 PMID: 22777593 DOI: 10.1007/s10096-012-1686-7
Source DB: PubMed Journal: Eur J Clin Microbiol Infect Dis ISSN: 0934-9723 Impact factor: 3.267