Literature DB >> 22777290

Challenges in sexual medicine.

Selim Cellek1, Annamaria Giraldi.   

Abstract

The sexual medicine field has been in mode of revolution until recently. Like all other fields of biomedical research, the economic situation around the world has had a negative impact on the field's momentum-research funding bodies, regulatory bodies and pharmaceutical companies seem to have placed sexual medicine in their low-priority list. But this is not the only challenge the field is facing. The successful development of phosphodiesterase type 5 (PDE5) inhibitors for treatment of erectile dysfunction (ED) means that research in this area seems to have slowed. However, there remain several unmet medical needs within sexual medicine such as premature ejaculation, severe ED and hypoactive sexual desire disorder, which await novel therapeutic approaches. Despite these challenges, research into finding and developing such therapies is likely to continue in the sexual medicine field, in an effort to improve the lives of our patients, who wait for effective therapies.

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Year:  2012        PMID: 22777290     DOI: 10.1038/nrurol.2012.134

Source DB:  PubMed          Journal:  Nat Rev Urol        ISSN: 1759-4812            Impact factor:   14.432


  57 in total

1.  A decade of change.

Authors:  John Arrowsmith
Journal:  Nat Rev Drug Discov       Date:  2012-01-03       Impact factor: 84.694

2.  2011 FDA drug approvals.

Authors:  Asher Mullard
Journal:  Nat Rev Drug Discov       Date:  2012-02-01       Impact factor: 84.694

3.  Boehringer Ingelheim withdraws libido drug for women.

Authors:  Jeanne Lenzer
Journal:  BMJ       Date:  2010-10-12

4.  Use of microdosing to predict pharmacokinetics at the therapeutic dose: experience with 5 drugs.

Authors:  Graham Lappin; Wilhelm Kuhnz; Roeline Jochemsen; Johannes Kneer; Ajai Chaudhary; Berend Oosterhuis; Willem Jan Drijfhout; Malcolm Rowland; R Colin Garner
Journal:  Clin Pharmacol Ther       Date:  2006-09       Impact factor: 6.875

Review 5.  Lessons from 60 years of pharmaceutical innovation.

Authors:  Bernard Munos
Journal:  Nat Rev Drug Discov       Date:  2009-12       Impact factor: 84.694

Review 6.  Physiology of women's sexual function: basic knowledge and new findings.

Authors:  Andrea Salonia; Annamaria Giraldi; Meredith L Chivers; Janniko R Georgiadis; Roy Levin; Kenneth R Maravilla; Margaret M McCarthy
Journal:  J Sex Med       Date:  2010-05-11       Impact factor: 3.802

7.  Treatment of hypoactive sexual desire disorder in premenopausal women: efficacy of flibanserin in the VIOLET Study.

Authors:  Leonard R Derogatis; Lawrence Komer; Molly Katz; Michèle Moreau; Toshio Kimura; Miguel Garcia; Glen Wunderlich; Robert Pyke
Journal:  J Sex Med       Date:  2012-01-16       Impact factor: 3.802

8.  Determinants of subjective experience of sexual arousal in women: feedback from genital arousal and erotic stimulus content.

Authors:  E Laan; W Everaerd; J van der Velde; J H Geer
Journal:  Psychophysiology       Date:  1995-09       Impact factor: 4.016

Review 9.  A Rho-kinase inhibitor, soluble guanylate cyclase activator and nitric oxide-releasing PDE5 inhibitor: novel approaches to erectile dysfunction.

Authors:  Selim Cellek; Rowland W Rees; Jas Kalsi
Journal:  Expert Opin Investig Drugs       Date:  2002-11       Impact factor: 6.206

10.  Intravaginal dehydroepiandrosterone (Prasterone), a physiological and highly efficient treatment of vaginal atrophy.

Authors:  Fernand Labrie; David Archer; Céline Bouchard; Michel Fortier; Leonello Cusan; José-Luis Gomez; Ginette Girard; Mira Baron; Normand Ayotte; Michèle Moreau; Robert Dubé; Isabelle Côté; Claude Labrie; Lyne Lavoie; Louise Berger; Lucy Gilbert; Céline Martel; John Balser
Journal:  Menopause       Date:  2009 Sep-Oct       Impact factor: 2.953

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  1 in total

1.  Bremelanotide for female sexual dysfunctions in premenopausal women: a randomized, placebo-controlled dose-finding trial.

Authors:  Anita H Clayton; Stanley E Althof; Sheryl Kingsberg; Leonard R DeRogatis; Robin Kroll; Irwin Goldstein; Jed Kaminetsky; Carl Spana; Johna Lucas; Robert Jordan; David J Portman
Journal:  Womens Health (Lond)       Date:  2016-05-16
  1 in total

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