OBJECTIVE: To report the incidence, demographics, and clinical findings among a population-based cohort of children with periocular infantile hemangiomas. METHODS: The medical records of all patients (<19 years of age) diagnosed as having periocular infantile hemangiomas while residing in Olmsted County, Minnesota, from January 1, 1965, through December 31, 2004, were retrospectively reviewed. RESULTS: Forty-three children were diagnosed as having periocular infantile hemangiomas during the 40-year period, yielding an incidence of 5.4 per 100,000 individuals younger than 19 years (95% CI, 3.8-7.1) or a birth prevalence of 1 in 1586 live births. Thirty children (70%) were female (P<.001). There was a history of maternal infertility in approximately 1 in 5 children and premature birth in 1 in 8 children. Twenty-six children (61%) had other abnormalities, including secondary hemangiomas in 9 (21%). Forty-one patients (95%) had unilateral disease, and 37 hemangiomas (86%) were located on the upper eyelid. CONCLUSIONS: In this population-based study, periocular infantile hemangiomas occurred in 1 in 1586 live births and were most prevalent on the unilateral upper eyelid of white female patients. Prevalent associations included maternal infertility and premature birth. Other abnormalities, including secondary hemangiomas in 1 in 5 children, were common in this cohort.
OBJECTIVE: To report the incidence, demographics, and clinical findings among a population-based cohort of children with periocular infantile hemangiomas. METHODS: The medical records of all patients (<19 years of age) diagnosed as having periocular infantile hemangiomas while residing in Olmsted County, Minnesota, from January 1, 1965, through December 31, 2004, were retrospectively reviewed. RESULTS: Forty-three children were diagnosed as having periocular infantile hemangiomas during the 40-year period, yielding an incidence of 5.4 per 100,000 individuals younger than 19 years (95% CI, 3.8-7.1) or a birth prevalence of 1 in 1586 live births. Thirty children (70%) were female (P<.001). There was a history of maternal infertility in approximately 1 in 5 children and premature birth in 1 in 8 children. Twenty-six children (61%) had other abnormalities, including secondary hemangiomas in 9 (21%). Forty-one patients (95%) had unilateral disease, and 37 hemangiomas (86%) were located on the upper eyelid. CONCLUSIONS: In this population-based study, periocular infantile hemangiomas occurred in 1 in 1586 live births and were most prevalent on the unilateral upper eyelid of white female patients. Prevalent associations included maternal infertility and premature birth. Other abnormalities, including secondary hemangiomas in 1 in 5 children, were common in this cohort.
Authors: Denise W Metry; Maria C Garzon; Beth A Drolet; Peter Frommelt; Anita Haggstrom; Judith Hall; Christopher P Hess; Geoffrey L Heyer; Dawn Siegel; Eulalia Baselga; William Katowitz; Moise L Levy; Anthony Mancini; Mandi L Maronn; Thuy Phung; Elena Pope; Grace Sun; Ilona J Frieden Journal: Pediatr Dermatol Date: 2009 Jul-Aug Impact factor: 1.588
Authors: D W Metry; A N Haggstrom; B A Drolet; E Baselga; S Chamlin; M Garzon; K Horii; A Lucky; A J Mancini; B Newell; A Nopper; G Heyer; I J Frieden Journal: Am J Med Genet A Date: 2006-05-01 Impact factor: 2.802
Authors: Anita N Haggstrom; Beth A Drolet; Eulalia Baselga; Sarah L Chamlin; Maria C Garzon; Kimberly A Horii; Anne W Lucky; Anthony J Mancini; Denise W Metry; Brandon Newell; Amy J Nopper; Ilona J Frieden Journal: Pediatrics Date: 2006-09 Impact factor: 7.124
Authors: Anita N Haggstrom; Beth A Drolet; Eulalia Baselga; Sarah L Chamlin; Maria C Garzon; Kimberly A Horii; Anne W Lucky; Anthony J Mancini; Denise W Metry; Brandon Newell; Amy J Nopper; Ilona J Frieden Journal: J Pediatr Date: 2007-03 Impact factor: 4.406
Authors: Mehdi Tavakoli; Saeid Yadegari; Mahnaz Mosallaei; Maryam Aletaha; Hossein Salour; Wendy W Lee Journal: J Ophthalmic Vis Res Date: 2017 Apr-Jun