OBJECTIVES: This study aimed at exploring the role of curcumin and taurine alone or in combination against cultured human hepatoma cells (Huh-7 cells). DESIGN AND METHODS: Huh-7 cells were plated and treated with various concentrations of curcumin and/or taurine. Hemocytometer cell count, cell viability, quantification of γ-IFN concentrations, and flow cytometric analyses for CD4, CD8, and CD25 were carried out. RESULTS: There were significant increases in the levels of cell density, γ-IFN, and CD8, accompanied with significant decrease in the level of CD4, when comparing cultured cells treated with curcumin and taurine with control cultured cells. CONCLUSION: Curcumin/taurine in combination formula is better treatment than single therapy, with respect to cell density and γ-IFN. Moreover, curcumin/taurine combined therapy enhances immunity by stimulating the CD4(+) T-helper cells with consequent induction of CD8 T-cell responses to lyse tumor cells.
OBJECTIVES: This study aimed at exploring the role of curcumin and taurine alone or in combination against cultured humanhepatoma cells (Huh-7 cells). DESIGN AND METHODS: Huh-7 cells were plated and treated with various concentrations of curcumin and/or taurine. Hemocytometer cell count, cell viability, quantification of γ-IFN concentrations, and flow cytometric analyses for CD4, CD8, and CD25 were carried out. RESULTS: There were significant increases in the levels of cell density, γ-IFN, and CD8, accompanied with significant decrease in the level of CD4, when comparing cultured cells treated with curcumin and taurine with control cultured cells. CONCLUSION:Curcumin/taurine in combination formula is better treatment than single therapy, with respect to cell density and γ-IFN. Moreover, curcumin/taurine combined therapy enhances immunity by stimulating the CD4(+) T-helper cells with consequent induction of CD8 T-cell responses to lyse tumor cells.
Authors: Stella Baliou; Anthony M Kyriakopoulos; Demetrios A Spandidos; Vassilios Zoumpourlis Journal: Int J Oncol Date: 2020-07-14 Impact factor: 5.650
Authors: Emad F Eskander; Ahmed A Abd-Rabou; Shaymaa M M Yahya; Ashraf El Sherbini; Mervat S Mohamed; Olfat G Shaker Journal: Indian J Clin Biochem Date: 2013-02-16
Authors: Stella Baliou; Maria Adamaki; Petros Ioannou; Aglaia Pappa; Mihalis I Panayiotidis; Demetrios A Spandidos; Ioannis Christodoulou; Anthony M Kyriakopoulos; Vassilis Zoumpourlis Journal: Mol Med Rep Date: 2021-06-29 Impact factor: 2.952