OBJECTIVE: Cardiovascular disease (CVD) mortality is reported to be lower in haemophilia patients than in the general population, but information on the occurrence of non-fatal CVD is lacking. The aim of our study was to assess CVD history in a cohort of living haemophilia patients. METHODS: Retrospective data on the occurrence of myocardial infarction, angina pectoris, ischaemic stroke and intracranial bleeding in 709 living Dutch and British haemophilia patients aged 30 yr or older were analysed and compared with the general age-matched male population. RESULTS: There was a trend towards a lower cumulative incidence of myocardial infarction (1.7% vs. 4.0%) and ischaemic stroke (0% vs. 1.5%) in patients with severe haemophilia than in the general population, while the occurrence of angina pectoris was similar (3.2 vs. 3.7%). As expected, the cumulative incidence of intracranial bleeding was, on the other hand, significantly increased in haemophilia patients (1.6% vs. 0.4% in the general population). CONCLUSION: Our results suggest a protective effect of severe haemophilia against acute ischaemic CVD.
OBJECTIVE:Cardiovascular disease (CVD) mortality is reported to be lower in haemophiliapatients than in the general population, but information on the occurrence of non-fatal CVD is lacking. The aim of our study was to assess CVD history in a cohort of living haemophiliapatients. METHODS: Retrospective data on the occurrence of myocardial infarction, angina pectoris, ischaemic stroke and intracranial bleeding in 709 living Dutch and British haemophiliapatients aged 30 yr or older were analysed and compared with the general age-matched male population. RESULTS: There was a trend towards a lower cumulative incidence of myocardial infarction (1.7% vs. 4.0%) and ischaemic stroke (0% vs. 1.5%) in patients with severe haemophilia than in the general population, while the occurrence of angina pectoris was similar (3.2 vs. 3.7%). As expected, the cumulative incidence of intracranial bleeding was, on the other hand, significantly increased in haemophiliapatients (1.6% vs. 0.4% in the general population). CONCLUSION: Our results suggest a protective effect of severe haemophilia against acute ischaemic CVD.
Authors: Suman L Sood; Dunlei Cheng; Margaret Ragni; Craig M Kessler; Doris Quon; Amy D Shapiro; Nigel S Key; Marilyn J Manco-Johnson; Adam Cuker; Christine Kempton; Tzu-Fei Wang; M Elaine Eyster; Philip Kuriakose; Annette von Drygalski; Joan Cox Gill; Allison Wheeler; Peter Kouides; Miguel A Escobar; Cindy Leissinger; Sarah Galdzicka; Marshall Corson; Crystal Watson; Barbara A Konkle Journal: Blood Adv Date: 2018-06-12
Authors: Shermarke Hassan; Rory C Monahan; Evelien P Mauser-Bunschoten; Lize F D van Vulpen; Jeroen Eikenboom; Erik A M Beckers; Louise Hooimeijer; Paula F Ypma; Laurens Nieuwenhuizen; Michiel Coppens; Saskia E M Schols; Frank W G Leebeek; Cees Smit; Mariëtte H Driessens; Saskia le Cessie; Erna C van Balen; Frits R Rosendaal; Johanna G van der Bom; Samantha C Gouw Journal: J Thromb Haemost Date: 2020-12-18 Impact factor: 5.824