AIMS: Little is known about the differential effects of independent and substance-induced major depression on the longitudinal course of alcohol, cocaine and heroin disorders when studied prospectively. DESIGN: Consecutively admitted in-patients, evaluated at baseline, 6-, 12- and 18-month follow-ups. SETTING: Baseline evaluations in a short-stay in-patient urban community psychiatric hospital unit. PARTICIPANTS: Adults (n = 250) with current DSM-IV cocaine, heroin and/or alcohol dependence at baseline. MEASUREMENTS: The Psychiatric Research Interview for Substance and Mental Disorders (PRISM), used to evaluate independent and substance-induced major depression, alcohol, cocaine and heroin dependence, and other psychiatric disorders. Outcomes for each substance: (i) time (weeks) from hospital discharge to first use; (ii) time from discharge to onset of sustained (≥26 weeks) remission from dependence; (iii) time from onset of sustained remission to relapse. FINDINGS: Substance-induced major depression significantly predicted post-discharge use of alcohol, cocaine and heroin (hazard ratios 4.7, 5.3 and 6.5, respectively). Among patients achieving stable remissions from dependence, independent major depression predicted relapse to alcohol and cocaine dependence (hazard ratios 2.3 and 2.7, respectively). CONCLUSIONS: Substance-induced and independent major depressions were both related to post-discharge use of alcohol, cocaine and heroin. The findings suggest the importance of clinical attention to both types of depression in substance abusing patients.
AIMS: Little is known about the differential effects of independent and substance-induced major depression on the longitudinal course of alcohol, cocaine and heroin disorders when studied prospectively. DESIGN: Consecutively admitted in-patients, evaluated at baseline, 6-, 12- and 18-month follow-ups. SETTING: Baseline evaluations in a short-stay in-patient urban community psychiatric hospital unit. PARTICIPANTS: Adults (n = 250) with current DSM-IV cocaine, heroin and/or alcohol dependence at baseline. MEASUREMENTS: The Psychiatric Research Interview for Substance and Mental Disorders (PRISM), used to evaluate independent and substance-induced major depression, alcohol, cocaine and heroin dependence, and other psychiatric disorders. Outcomes for each substance: (i) time (weeks) from hospital discharge to first use; (ii) time from discharge to onset of sustained (≥26 weeks) remission from dependence; (iii) time from onset of sustained remission to relapse. FINDINGS: Substance-induced major depression significantly predicted post-discharge use of alcohol, cocaine and heroin (hazard ratios 4.7, 5.3 and 6.5, respectively). Among patients achieving stable remissions from dependence, independent major depression predicted relapse to alcohol and cocaine dependence (hazard ratios 2.3 and 2.7, respectively). CONCLUSIONS: Substance-induced and independent major depressions were both related to post-discharge use of alcohol, cocaine and heroin. The findings suggest the importance of clinical attention to both types of depression in substance abusing patients.
Authors: K M Carroll; S A Ball; C Nich; P G O'Connor; D A Eagan; T L Frankforter; E G Triffleman; J Shi; B J Rounsaville Journal: Arch Gen Psychiatry Date: 2001-08
Authors: M Russell; J R Marshall; M Trevisan; J L Freudenheim; A W Chan; N Markovic; J E Vána; R L Priore Journal: Am J Epidemiol Date: 1997-12-01 Impact factor: 4.897
Authors: R A Brown; P M Monti; M G Myers; R A Martin; T Rivinus; M E Dubreuil; D J Rohsenow Journal: Am J Psychiatry Date: 1998-02 Impact factor: 18.112
Authors: Stephanie S O'Malley; Rajita Sinha; Carlos M Grilo; Christy Capone; Conor K Farren; Sherry A McKee; Bruce J Rounsaville; Ran Wu Journal: Alcohol Clin Exp Res Date: 2007-04 Impact factor: 3.455
Authors: Raymond F Anton; Stephanie S O'Malley; Domenic A Ciraulo; Ron A Cisler; David Couper; Dennis M Donovan; David R Gastfriend; James D Hosking; Bankole A Johnson; Joseph S LoCastro; Richard Longabaugh; Barbara J Mason; Margaret E Mattson; William R Miller; Helen M Pettinati; Carrie L Randall; Robert Swift; Roger D Weiss; Lauren D Williams; Allen Zweben Journal: JAMA Date: 2006-05-03 Impact factor: 56.272
Authors: David McDowell; Edward V Nunes; Angela M Seracini; Jami Rothenberg; Suzanne K Vosburg; Guoguang J Ma; Eva Petkova Journal: Drug Alcohol Depend Date: 2005-11-01 Impact factor: 4.492
Authors: Nora D Volkow; Marta Torrens; Vladimir Poznyak; Elizabeth Sáenz; Anja Busse; Wataru Kashino; Dzmitry Krupchanka; Devora Kestel; Giovanna Campello; Gilberto Gerra Journal: World Psychiatry Date: 2020-10 Impact factor: 49.548
Authors: R Kathryn McHugh; Dawn E Sugarman; Laurel Meyer; Garrett M Fitzmaurice; Shelly F Greenfield Journal: Drug Alcohol Depend Date: 2019-12-23 Impact factor: 4.492
Authors: Sara N Levintow; Brian W Pence; Tran Viet Ha; Nguyen Le Minh; Teerada Sripaipan; Carl A Latkin; Pham The Vu; Vu Minh Quan; Constantine Frangakis; Vivian F Go Journal: AIDS Behav Date: 2019-03
Authors: Benjamin Keller; Joan-Ignasi Mestre-Pinto; María Álvaro-Bartolomé; Diana Martinez-Sanvisens; Magí Farre; M Julia García-Fuster; Jesús A García-Sevilla; Marta Torrens Journal: Front Psychiatry Date: 2017-12-01 Impact factor: 4.157