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Literature DB >> 22773925

New Insights into the Molecular Basis of the Antiphospholipid Syndrome.

Abstract

Antiphospholipid syndrome is an autoimmune disease characterized by the presence of circulating antiphospholipid antibodies (aPL) that promote thrombosis, pregnancy complications and cardiovascular diseases. Alterations in the function of vascular cells induced by aPL underlie these outcomes. This review will discuss recent findings that indicate a novel mechanism by which aPL antagonize endothelial cell production of nitric oxide and thereby promote thrombosis.

Entities: Chemical Disease Gene Species

Year: 2011 PMID： 22773925 PMCID： PMC3389810 DOI： 10.1016/j.ddmec.2011.12.002

Source DB: PubMed Journal: Drug Discov Today Dis Mech ISSN： 1740-6765

47 in total

Review 1. Nitric oxide insufficiency, platelet activation, and arterial thrombosis.

Authors: J Loscalzo
Journal: Circ Res Date: 2001-04-27 Impact factor: 17.367

Review 2. Regulation of endothelial nitric oxide synthase: location, location, location.

Authors: Philip W Shaul
Journal: Annu Rev Physiol Date: 2002 Impact factor: 19.318

3. Endothelial function is impaired in patients with primary antiphospholipid syndrome.

Authors: Monika Stalc; Pavel Poredos; Polona Peternel; Matija Tomsic; Miran Sebestjen; Tanja Kveder
Journal: Thromb Res Date: 2005-11-07 Impact factor: 3.944

Review 4. Current concepts on the pathogenesis of the antiphospholipid syndrome.

Authors: Bill Giannakopoulos; Freda Passam; Soheila Rahgozar; Steven A Krilis
Journal: Blood Date: 2006-09-19 Impact factor: 22.113

5. Apolipoprotein E receptor 2 is involved in the thrombotic complications in a murine model of the antiphospholipid syndrome.

Authors: Zurina Romay-Penabad; Renan Aguilar-Valenzuela; Rolf T Urbanus; Ronald H W M Derksen; Maarten T T Pennings; Elizabeth Papalardo; Tuya Shilagard; Gracie Vargas; Yong Hwang; Philip G de Groot; Silvia S Pierangeli
Journal: Blood Date: 2010-11-30 Impact factor: 22.113

Review 6. Pathogenesis of antiphospholipid syndrome: understanding the antibodies.

Authors: Pier Luigi Meroni; M Orietta Borghi; Elena Raschi; Francesco Tedesco
Journal: Nat Rev Rheumatol Date: 2011-05-10 Impact factor: 20.543

Review 7. Intracellular signaling triggered by antiphospholipid antibodies in platelets and endothelial cells: a pathway to targeted therapies.

Authors: Silvia S Pierangeli; Mariano Vega-Ostertag; E Nigel Harris
Journal: Thromb Res Date: 2004 Impact factor: 3.944

Review 8. Autoimmune-mediated atherothrombosis.

Authors: E Matsuura; L R Lopez
Journal: Lupus Date: 2008-10 Impact factor: 2.911

9. Patients with antiphospholipid syndrome display endothelial perturbation.

Authors: Massimo Cugno; Maria Orietta Borghi; Laura Maria Lonati; Lorenzo Ghiadoni; Maria Gerosa; Claudia Grossi; Valentina De Angelis; Gaia Magnaghi; Angela Tincani; Daniela Mari; Piersandro Riboldi; Pier Luigi Meroni
Journal: J Autoimmun Date: 2009-08-04 Impact factor: 7.094

New Insights into the Molecular Basis of the Antiphospholipid Syndrome.

Review 1. Nitric oxide insufficiency, platelet activation, and arterial thrombosis.

Review 2. Regulation of endothelial nitric oxide synthase: location, location, location.

3. Endothelial function is impaired in patients with primary antiphospholipid syndrome.

Review 4. Current concepts on the pathogenesis of the antiphospholipid syndrome.

5. Apolipoprotein E receptor 2 is involved in the thrombotic complications in a murine model of the antiphospholipid syndrome.

Review 6. Pathogenesis of antiphospholipid syndrome: understanding the antibodies.

Review 7. Intracellular signaling triggered by antiphospholipid antibodies in platelets and endothelial cells: a pathway to targeted therapies.

Review 8. Autoimmune-mediated atherothrombosis.

9. Patients with antiphospholipid syndrome display endothelial perturbation.

Review 10. Antiphospholipid antibodies and the antiphospholipid syndrome: pathogenic mechanisms.

1. Recurrent, spontaneous esophageal ruptures associated with antiphospholipid antibody syndrome: report of a case.

2. [Primary antiphospholipid syndrome: newly developed leg ulcer and history of stroke].

3. Prevalence and coagulation correlation of anticardiolipin antibodies in patients with COVID-19.

Review 4. Inhibition of nitric oxide and antiphospholipid antibody-mediated thrombosis.

Review 5. Aspirin: The Mechanism of Action Revisited in the Context of Pregnancy Complications.