Literature DB >> 22772887

[Th9 cells. Functionally important or just an epiphenomenon?].

A Ramming1, H Schulze-Koops, A Skapenko.   

Abstract

Development of the recently described Th9 cells is selectively and dynamically controlled by epigenetic modifications. The selective epigenetic inactivation of the PU.1 promoter associated with diminished Th9 cell differentiation by naive CD4 T cells allows the assumption of a special physiologic role of IL-9. Once deregulated, IL-9 seems to play an important role in the pathogenesis of several autoimmune disorders.

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Year:  2012        PMID： 22772887     DOI： 10.1007/s00393-011-0942-z

Source DB:  PubMed          Journal:  Z Rheumatol        ISSN： 0340-1855            Impact factor:   1.372


  22 in total

1.  The development of inflammatory T(H)-17 cells requires interferon-regulatory factor 4.

Authors:  Anne Brüstle; Sylvia Heink; Magdalena Huber; Christine Rosenplänter; Christine Stadelmann; Philipp Yu; Enrico Arpaia; Tak W Mak; Thomas Kamradt; Michael Lohoff
Journal:  Nat Immunol       Date:  2007-08-05       Impact factor: 25.606

2.  Mast cells are essential intermediaries in regulatory T-cell tolerance.

Authors:  Li-Fan Lu; Evan F Lind; David C Gondek; Kathy A Bennett; Michael W Gleeson; Karina Pino-Lagos; Zachary A Scott; Anthony J Coyle; Jennifer L Reed; Jacques Van Snick; Terry B Strom; Xin Xiao Zheng; Randolph J Noelle
Journal:  Nature       Date:  2006-08-20       Impact factor: 49.962

3.  Crystal structure of PU.1/IRF-4/DNA ternary complex.

Authors:  Carlos R Escalante; Abraham L Brass; Jagan M R Pongubala; Ella Shatova; Leyi Shen; Harinder Singh; Aneel K Aggarwal
Journal:  Mol Cell       Date:  2002-11       Impact factor: 17.970

Review 4.  Cellular sources and immune functions of interleukin-9.

Authors:  Randolph J Noelle; Elizabeth C Nowak
Journal:  Nat Rev Immunol       Date:  2010-09-17       Impact factor: 53.106

5.  IL-9 as a mediator of Th17-driven inflammatory disease.

Authors:  Elizabeth C Nowak; Casey T Weaver; Henrietta Turner; Sakhina Begum-Haque; Burkhard Becher; Bettina Schreiner; Anthony J Coyle; Lloyd H Kasper; Randolph J Noelle
Journal:  J Exp Med       Date:  2009-07-13       Impact factor: 14.307

6.  IL-9 increases the expression of several cytokines in activated mast cells, while the IL-9-induced IL-9 production is inhibited in mast cells of histamine-free transgenic mice.

Authors:  Zoltan Wiener; Andras Falus; Sara Toth
Journal:  Cytokine       Date:  2004-05-07       Impact factor: 3.861

7.  IL-9 induces differentiation of TH17 cells and enhances function of FoxP3+ natural regulatory T cells.

Authors:  Wassim Elyaman; Elizabeth M Bradshaw; Catherine Uyttenhove; Valérie Dardalhon; Amit Awasthi; Jaime Imitola; Estelle Bettelli; Mohamed Oukka; Jacques van Snick; Jean-Christophe Renauld; Vijay K Kuchroo; Samia J Khoury
Journal:  Proc Natl Acad Sci U S A       Date:  2009-05-11       Impact factor: 11.205

8.  The transcription factor PU.1 is required for the development of IL-9-producing T cells and allergic inflammation.

Authors:  Hua-Chen Chang; Sarita Sehra; Ritobrata Goswami; Weiguo Yao; Qing Yu; Gretta L Stritesky; Rukhsana Jabeen; Carl McKinley; Ayele-Nati Ahyi; Ling Han; Evelyn T Nguyen; Michael J Robertson; Narayanan B Perumal; Robert S Tepper; Stephen L Nutt; Mark H Kaplan
Journal:  Nat Immunol       Date:  2010-05-02       Impact factor: 25.606

9.  Interferon regulatory factor 4 (IRF4) interacts with NFATc2 to modulate interleukin 4 gene expression.

Authors:  Jyothi Rengarajan; Kerri A Mowen; Kathryn D McBride; Erica D Smith; Harinder Singh; Laurie H Glimcher
Journal:  J Exp Med       Date:  2002-04-15       Impact factor: 14.307

10.  IL-4 inhibits TGF-beta-induced Foxp3+ T cells and, together with TGF-beta, generates IL-9+ IL-10+ Foxp3(-) effector T cells.

Authors:  Valérie Dardalhon; Amit Awasthi; Hyoung Kwon; George Galileos; Wenda Gao; Raymond A Sobel; Meike Mitsdoerffer; Terry B Strom; Wassim Elyaman; I-Cheng Ho; Samia Khoury; Mohamed Oukka; Vijay K Kuchroo
Journal:  Nat Immunol       Date:  2008-11-09       Impact factor: 25.606
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  2 in total

1.  Increased Serum Interleukin-9 Levels in Rheumatoid Arthritis and Systemic Lupus Erythematosus: Pathogenic Role or Just an Epiphenomenon?

Authors:  Andréa Tavares Dantas; Claudia Diniz Lopes Marques; Laurindo Ferreira da Rocha Junior; Mariana Brayner Cavalcanti; Sayonara Maria Calado Gonçalves; Pablo Ramon Gualberto Cardoso; Henrique de Ataide Mariz; Moacyr Jesus Barreto de Melo Rego; Angela Luzia Branco Pinto Duarte; Ivan da Rocha Pitta; Maira Galdino da Rocha Pitta
Journal:  Dis Markers       Date:  2015-05-19       Impact factor: 3.434

2.  Expression and role of interleukin-9 in Vogt-Koyanagi-Harada disease.

Authors:  Zhixi Peng; Shaoqiu Jiang; Mingxing Wu; Xiyuan Zhou; Qian Wang
Journal:  Mol Vis       Date:  2017-07-31       Impact factor: 2.367
  2 in total

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