PURPOSE OF REVIEW: This review describes the most recent advances in epidemiology, classification, genetics, pathology and treatment of essential tremor. In addition, recent advances in more rare forms of tremor are summarized. RECENT FINDINGS: Clinical, biochemical, pathological and imaging studies suggest an abnormal functioning of the cerebellum in essential tremor. Minor changes of cognition and personality may be due to secondary effects. Dementia and possible shortened life span seem to be limited to late-onset essential tremor. Many of these issues are not yet finally settled and need confirmation in further studies. The current essential tremor classification seems not to reflect the variety of phenotypic expressions. Regarding treatment, there is now a level B evidence for topiramate. Levetiracetam may induce a positive response in Holmes tremor, but is ineffective in orthostatic tremor. SUMMARY: These findings have extended our knowledge about essential tremor. It appears that a new, more distinct classification system is required. Recent treatments have remained unchanged.
PURPOSE OF REVIEW: This review describes the most recent advances in epidemiology, classification, genetics, pathology and treatment of essential tremor. In addition, recent advances in more rare forms of tremor are summarized. RECENT FINDINGS: Clinical, biochemical, pathological and imaging studies suggest an abnormal functioning of the cerebellum in essential tremor. Minor changes of cognition and personality may be due to secondary effects. Dementia and possible shortened life span seem to be limited to late-onset essential tremor. Many of these issues are not yet finally settled and need confirmation in further studies. The current essential tremor classification seems not to reflect the variety of phenotypic expressions. Regarding treatment, there is now a level B evidence for topiramate. Levetiracetam may induce a positive response in Holmes tremor, but is ineffective in orthostatic tremor. SUMMARY: These findings have extended our knowledge about essential tremor. It appears that a new, more distinct classification system is required. Recent treatments have remained unchanged.
Authors: Jae Hyun Woo; Bo Young Hong; Joon Sung Kim; Seok Ho Moon; Soo Yeon Kim; Hye Young Han; Dong Yoon Park; Seong Hoon Lim Journal: Ann Rehabil Med Date: 2013-08-26
Authors: Natalia González Rojas; Martin Cesarini; José Luis Etcheverry; Gustavo Da Prat; Tomás Viera Aramburu; Emilia Mabel Gatto Journal: Tremor Other Hyperkinet Mov (N Y) Date: 2018-06-26