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Literature DB >> 22772543

After Xigris, researchers look to new targets to combat sepsis.

Sarah C P Williams.

Abstract

Entities: Disease

Mesh：

Substances：

Year: 2012 PMID： 22772543 DOI： 10.1038/nm0712-1001

Source DB: PubMed Journal: Nat Med ISSN： 1078-8956 Impact factor: 53.440

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2 in total

1. Early use of polymyxin B hemoperfusion in abdominal septic shock: the EUPHAS randomized controlled trial.

Authors: Dinna N Cruz; Massimo Antonelli; Roberto Fumagalli; Francesca Foltran; Nicola Brienza; Abele Donati; Vincenzo Malcangi; Flavia Petrini; Giada Volta; Franco M Bobbio Pallavicini; Federica Rottoli; Francesco Giunta; Claudio Ronco
Journal: JAMA Date: 2009-06-17 Impact factor: 56.272

2. A placebo-controlled, double-blind, dose-escalation study to assess the safety, tolerability and pharmacokinetics/pharmacodynamics of single and multiple intravenous infusions of AZD9773 in patients with severe sepsis and septic shock.

Authors: Peter E Morris; Brian Zeno; Andrew C Bernard; Xiangning Huang; Shampa Das; Timi Edeki; Steven G Simonson; Gordon R Bernard
Journal: Crit Care Date: 2012-02-17 Impact factor: 9.097

2 in total

32 in total

1. Zinc dyshomeostasis during polymicrobial sepsis in mice involves zinc transporter Zip14 and can be overcome by zinc supplementation.

Authors: Inga Wessels; Robert J Cousins
Journal: Am J Physiol Gastrointest Liver Physiol Date: 2015-08-13 Impact factor: 4.052

Review 2. Platelet function beyond hemostasis and thrombosis.

Authors: Jerry Ware; Adam Corken; Reshma Khetpal
Journal: Curr Opin Hematol Date: 2013-09 Impact factor: 3.284

Review 3. To hydrolyze or not to hydrolyze: the dilemma of platelet-activating factor acetylhydrolase.

Authors: Gopal Kedihitlu Marathe; Chaitanya Pandit; Chikkamenahalli Lakshminarayana Lakshmikanth; Vyala Hanumanthareddy Chaithra; Shancy Petsel Jacob; Cletus Joseph Michael D'Souza
Journal: J Lipid Res Date: 2014-05-23 Impact factor: 5.922

4. The anti-inflammatory effect of combined complement and CD14 inhibition is preserved during escalating bacterial load.

Authors: Kjetil H Egge; Andreas Barratt-Due; Stig Nymo; Julie K Lindstad; Anne Pharo; Corinna Lau; Terje Espevik; Ebbe B Thorgersen; Tom E Mollnes
Journal: Clin Exp Immunol Date: 2015-07-19 Impact factor: 4.330

5. Pro-inflammatory effects of matrix metalloproteinase 7 in acute inflammation.

Authors: R E Vandenbroucke; I Vanlaere; F Van Hauwermeiren; E Van Wonterghem; C Wilson; C Libert
Journal: Mucosal Immunol Date: 2013-10-16 Impact factor: 7.313

Review 6. Sepsis: in search of cure.

Authors: Chikkamenahalli Lakshminarayana Lakshmikanth; Shancy Petsel Jacob; Vyala Hanumanthareddy Chaithra; Hugo Caire de Castro-Faria-Neto; Gopal Kedihithlu Marathe
Journal: Inflamm Res Date: 2016-03-19 Impact factor: 4.575

After Xigris, researchers look to new targets to combat sepsis.

1. Early use of polymyxin B hemoperfusion in abdominal septic shock: the EUPHAS randomized controlled trial.

2. A placebo-controlled, double-blind, dose-escalation study to assess the safety, tolerability and pharmacokinetics/pharmacodynamics of single and multiple intravenous infusions of AZD9773 in patients with severe sepsis and septic shock.

1. Zinc dyshomeostasis during polymicrobial sepsis in mice involves zinc transporter Zip14 and can be overcome by zinc supplementation.

Review 2. Platelet function beyond hemostasis and thrombosis.

Review 3. To hydrolyze or not to hydrolyze: the dilemma of platelet-activating factor acetylhydrolase.

4. The anti-inflammatory effect of combined complement and CD14 inhibition is preserved during escalating bacterial load.

5. Pro-inflammatory effects of matrix metalloproteinase 7 in acute inflammation.

Review 6. Sepsis: in search of cure.

7. Proteome analysis of hemofilter adsorbates to identify novel substances of sepsis: a pilot study.

Review 8. Immunosuppression in sepsis: a novel understanding of the disorder and a new therapeutic approach.

Review 9. Carbon monoxide in the treatment of sepsis.

10. NFI-A disrupts myeloid cell differentiation and maturation in septic mice.