| Literature DB >> 22772483 |
Seiya Harada1, Tomoichiro Oka, Eisuke Tokuoka, Naoko Kiyota, Koichi Nishimura, Yasushi Shimada, Takehiko Ueno, Shigeru Ikezawa, Takaji Wakita, Qiuhong Wang, Linda J Saif, Kazuhiko Katayama.
Abstract
Sapovirus (SaV) is an important pathogen that causes acute gastroenteritis in humans. Human SaV is highly diverse genetically and is classified into multiple genogroups and genotypes. At present, there is no clear evidence for gastroenteritis cases caused by re-infection with SaV. We found that two individuals were sequentially infected with SaVs of two different genogroups and had gastroenteritis after each infection, although in one of the subsequent cases, both SaV and norovirus were detected. We also found a genetic shift in SaVs from gastroenteritis outpatients in the same geographical location. Our results suggest that protective immunity may be at least genogroup-specific for SaV.Entities:
Mesh：
Year: 2012 PMID： 22772483 DOI： 10.1007/s00705-012-1387-7
Source DB: PubMed Journal: Arch Virol ISSN： 0304-8608 Impact factor: 2.574