| Literature DB >> 22771861 |
Hong You1, Geoffrey N Gobert, Mary G Duke, Wenbao Zhang, Yuesheng Li, Malcolm K Jones, Donald P McManus.
Abstract
Insulin receptors have been previously identified in Schistosoma japonicum that can bind human insulin. We used the purified recombined protein of the ligand domain of S.japonicum insulin receptor 2 (SjLD2) in three independent murine vaccine/challenge trials. Compared with controls, vaccination of mice with SjLD2 resulted in a significant reduction in faecal eggs, the stunting of adult worms and a reduction in liver granuloma density in all three trials. Furthermore, in the final trial, in which mature intestinal eggs were also quantified, there was a reduction in their number. These results suggest that development of a vaccine based on rSjLD2 for preventing transmission of zoonotic schistosomiasis is feasible.Entities:
Mesh：
Substances：
Year: 2012 PMID： 22771861 DOI： 10.1016/j.ijpara.2012.06.002
Source DB: PubMed Journal: Int J Parasitol ISSN： 0020-7519 Impact factor: 3.981