| Literature DB >> 22771476 |
Xuan Zhang1, Xiaona You, Nan Li, Weiying Zhang, Sarantis Gagos, Qi Wang, Aggelos Banos, Na Cai, Huakun Zhang, Hang Zhang, Xuezhi Zhang, Changliang Shan, Liyan Qiu, Shuai Zhang, Na Lv, Minshan Chen, Yumei Du, Jianchuan Xia, Lihong Ye, Xiaodong Zhang.
Abstract
The significance of hepatitis B virus (HBV) DNA-based integration in hepatocarcinogenesis is poorly understood. In the present study, we investigated whether the integration of HBV X gene (HBx) is involved in the event. Our finding showed that the integration of HBx fragment (316-462 bp/262-462 bp) was able to transform human immortalized normal liver LO2 cells using a cell model of HBx-integration. We identified that the recombination, HBx/Alu core sequence/subtelomeric DNA, was required for the transformation, which could be detected in 5 out of 44 clinical HBx-positive hepatocellular carcinoma tissues. Thus, we conclude that HBx integration is involved in the hepatocarcinogenesis.Entities:
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Year: 2012 PMID： 22771476 DOI： 10.1016/j.febslet.2012.06.039
Source DB: PubMed Journal: FEBS Lett ISSN： 0014-5793 Impact factor: 4.124