Rafael Salido-Vallejo1, María José Linares-Sicilia2, Gloria Garnacho-Saucedo3, Marina Sánchez-Frías4, Francisco Solís-Cuesta5, Josepa Gené6, José Carlos Moreno-Giménez3. 1. Department of Dermatology, Hospital Universitario Reina Sofía, Córdoba, Spain. Electronic address: rsalidovallejo@aedv.es. 2. Department of Microbiology, Faculty of Medicine, Universidad de Córdoba, Córdoba, Spain. 3. Department of Dermatology, Hospital Universitario Reina Sofía, Córdoba, Spain. 4. Department of Pathology, Hospital Universitario Reina Sofía, Córdoba, Spain. 5. Department of Microbiology, Faculty of Medicine, Universidad de Córdoba, Córdoba, Spain; Department of Microbiology, Hospital Universitario Reina Sofía, Faculty of Medicine, Universidad de Córdoba, Córdoba, Spain. 6. Microbiology Unit, Faculty of Medicine and Health Sciences, Universitat Rovira i Virgili, Reus, Spain.
Abstract
BACKGROUND: Phaeohyphomycosis can be caused by a number of different species, being the most common Alternaria alternata and Alternaria infectoria. The biggest risk factor for the development of the infection is immunosuppression. AIMS: We present the case of a 64-year-old male renal transplant patient who came to hospital for presenting a tumour in the Achilles region which had been gradually growing in size. METHODS: A skin biopsy was taken for histological study and culture of fungi and mycobacteria. Blood tests and imaging studies were performed. RESULTS: Histopathology study and cultures identified A. infectoria as the causal agent. Imaging studies ruled out internal foci of infection. The lesion was surgically removed with no signs of recurrence after 24 months of follow-up. CONCLUSIONS: There are no treatment guidelines at present for cutaneous and subcutaneous Alternaria spp. infections. Various systemic antifungals have been used, either in combination with surgical removal or alone, with varying results. Surgery alone could be useful in the treatment of solitary, localised lesions in transplant patients in whom there are difficulties in controlling immunosuppression.
BACKGROUND:Phaeohyphomycosis can be caused by a number of different species, being the most common Alternaria alternata and Alternaria infectoria. The biggest risk factor for the development of the infection is immunosuppression. AIMS: We present the case of a 64-year-old male renal transplant patient who came to hospital for presenting a tumour in the Achilles region which had been gradually growing in size. METHODS: A skin biopsy was taken for histological study and culture of fungi and mycobacteria. Blood tests and imaging studies were performed. RESULTS: Histopathology study and cultures identified A. infectoria as the causal agent. Imaging studies ruled out internal foci of infection. The lesion was surgically removed with no signs of recurrence after 24 months of follow-up. CONCLUSIONS: There are no treatment guidelines at present for cutaneous and subcutaneous Alternaria spp. infections. Various systemic antifungals have been used, either in combination with surgical removal or alone, with varying results. Surgery alone could be useful in the treatment of solitary, localised lesions in transplant patients in whom there are difficulties in controlling immunosuppression.
Authors: Walmar Roncalli Pereira de Oliveira; Maria Fernanda Longo Borsato; Maria Luiza Ducati Dabronzo; Cyro Festa Neto; Larissa Aragão Rocha; Ricardo Spina Nunes Journal: An Bras Dermatol Date: 2016 Jan-Feb Impact factor: 1.896
Authors: Pavlina Lyskova; Milos Kubanek; Vit Hubka; Eva Sticova; Ludek Voska; Dana Kautznerova; Miroslav Kolarik; Petr Hamal; Martina Vasakova Journal: Mycopathologia Date: 2016-11-19 Impact factor: 2.574
Authors: Maria Claudia Carvas Passarelli Tirico; Cyro F Neto; Lana L Cruz; Antonio Ferreira Mendes-Sousa; Desirée Esther J Valkinir; Ricardo Spina; Walmar R P Oliveira Journal: JAAD Case Rep Date: 2016-12-05