Literature DB >> 22771053

Resistance to diabetes-promoting lifestyle factors -- what is the mechanism?

Hubert Kolb1.   

Abstract

Not all people exposed to diabetes-promoting lifestyle factors progress to overt type 2 diabetes. The emerging concept of hormesis provides an explanation for the resistance to metabolic stress. Hormesis requires limited stress or damage which elicits an adaptive repair and protective response which renders the organism resistant to further metabolic stress.
Copyright © 2012 Elsevier Ireland Ltd. All rights reserved.

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Year:  2012        PMID: 22771053     DOI: 10.1016/j.diabres.2012.06.006

Source DB:  PubMed          Journal:  Diabetes Res Clin Pract        ISSN: 0168-8227            Impact factor:   5.602


  1 in total

1.  Mild exposure of RIN-5F β-cells to human islet amyloid polypeptide aggregates upregulates antioxidant enzymes via NADPH oxidase-RAGE: an hormetic stimulus.

Authors:  Elisabetta Borchi; Valentina Bargelli; Valentina Guidotti; Andrea Berti; Massimo Stefani; Chiara Nediani; Stefania Rigacci
Journal:  Redox Biol       Date:  2013-12-17       Impact factor: 11.799

  1 in total

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