Literature DB >> 22770959

Sonic Hedgehog in pancreatic cancer: from bench to bedside, then back to the bench.

David E Rosow1, Andrew S Liss, Oliver Strobel, Stefan Fritz, Dirk Bausch, Nakul P Valsangkar, Janivette Alsina, Birte Kulemann, Joo Kyung Park, Junpei Yamaguchi, Jennifer LaFemina, Sarah P Thayer.   

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Year:  2012        PMID： 22770959      PMCID： PMC3806061          DOI： 10.1016/j.surg.2012.05.030

Source DB:  PubMed          Journal:  Surgery        ISSN： 0039-6060            Impact factor:   3.982


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  67 in total

Review 1.  The Hedgehog and Wnt signalling pathways in cancer.

Authors:  J Taipale; P A Beachy
Journal:  Nature       Date:  2001-05-17       Impact factor: 49.962

2.  Sonic hedgehog induces angiogenesis via Rho kinase-dependent signaling in endothelial cells.

Authors:  Marie-Ange Renault; Jérôme Roncalli; Jörn Tongers; Tina Thorne; Ekaterina Klyachko; Sol Misener; Olga V Volpert; Shanu Mehta; Aaron Burg; Corinne Luedemann; Gangjian Qin; Raj Kishore; Douglas W Losordo
Journal:  J Mol Cell Cardiol       Date:  2010-05-15       Impact factor: 5.000

Review 3.  Mechanisms of Hedgehog pathway activation in cancer and implications for therapy.

Authors:  Suzie J Scales; Frederic J de Sauvage
Journal:  Trends Pharmacol Sci       Date:  2009-05-13       Impact factor: 14.819

4.  Sonic hedgehog promotes desmoplasia in pancreatic cancer.

Authors:  Jennifer M Bailey; Benjamin J Swanson; Tomofumi Hamada; John P Eggers; Pankaj K Singh; Thomas Caffery; Michel M Ouellette; Michael A Hollingsworth
Journal:  Clin Cancer Res       Date:  2008-10-01       Impact factor: 12.531

5.  Identification of pancreatic cancer stem cells.

Authors:  Chenwei Li; David G Heidt; Piero Dalerba; Charles F Burant; Lanjing Zhang; Volkan Adsay; Max Wicha; Michael F Clarke; Diane M Simeone
Journal:  Cancer Res       Date:  2007-02-01       Impact factor: 12.701

6.  Sonic hedgehog directs specialised mesoderm differentiation in the intestine and pancreas.

Authors:  A Apelqvist; U Ahlgren; H Edlund
Journal:  Curr Biol       Date:  1997-10-01       Impact factor: 10.834

7.  Distribution of Indian hedgehog and its receptors patched and smoothened in human chronic pancreatitis.

Authors:  H Kayed; J Kleeff; S Keleg; M W Büchler; H Friess
Journal:  J Endocrinol       Date:  2003-09       Impact factor: 4.286

8.  Enhanced expression of vascular endothelial growth factor in human pancreatic cancer correlates with local disease progression.

Authors:  J Itakura; T Ishiwata; H Friess; H Fujii; Y Matsumoto; M W Büchler; M Korc
Journal:  Clin Cancer Res       Date:  1997-08       Impact factor: 12.531

9.  A paracrine requirement for hedgehog signalling in cancer.

Authors:  Robert L Yauch; Stephen E Gould; Suzie J Scales; Tracy Tang; Hua Tian; Christina P Ahn; Derek Marshall; Ling Fu; Thomas Januario; Dara Kallop; Michelle Nannini-Pepe; Karen Kotkow; James C Marsters; Lee L Rubin; Frederic J de Sauvage
Journal:  Nature       Date:  2008-08-27       Impact factor: 49.962

10.  Inhibition of ocular neovascularization by hedgehog blockade.

Authors:  Enrico M Surace; Kamaljit S Balaggan; Alessandra Tessitore; Claudio Mussolino; Gabriella Cotugno; Ciro Bonetti; Aniello Vitale; Robin R Ali; Alberto Auricchio
Journal:  Mol Ther       Date:  2005-12-15       Impact factor: 11.454
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  15 in total

1.  Stromal response to Hedgehog signaling restrains pancreatic cancer progression.

Authors:  John J Lee; Rushika M Perera; Huaijun Wang; Dai-Chen Wu; X Shawn Liu; Shiwei Han; Julien Fitamant; Phillip D Jones; Krishna S Ghanta; Sally Kawano; Julia M Nagle; Vikram Deshpande; Yves Boucher; Tomoyo Kato; James K Chen; Jürgen K Willmann; Nabeel Bardeesy; Philip A Beachy
Journal:  Proc Natl Acad Sci U S A       Date:  2014-07-14       Impact factor: 11.205

Review 2.  Nanomedicine strategies to overcome the pathophysiological barriers of pancreatic cancer.

Authors:  Pavan P Adiseshaiah; Rachael M Crist; Sara S Hook; Scott E McNeil
Journal:  Nat Rev Clin Oncol       Date:  2016-08-17       Impact factor: 66.675

Review 3.  Differential role of Hedgehog signaling in human pancreatic (patho-) physiology: An up to date review.

Authors:  Eckhard Klieser; Stefan Swierczynski; Christian Mayr; Tarkan Jäger; Johanna Schmidt; Daniel Neureiter; Tobias Kiesslich; Romana Illig
Journal:  World J Gastrointest Pathophysiol       Date:  2016-05-15

4.  Development of thieno- and benzopyrimidinone inhibitors of the Hedgehog signaling pathway reveals PDE4-dependent and PDE4-independent mechanisms of action.

Authors:  Jonathan E Hempel; Adrian G Cadar; Charles C Hong
Journal:  Bioorg Med Chem Lett       Date:  2016-03-07       Impact factor: 2.823

5.  Modulation of redox metabolism negates cancer-associated fibroblasts-induced treatment resistance in a heterotypic 3D culture platform of pancreatic cancer.

Authors:  Mans Broekgaarden; Sriram Anbil; Anne-Laure Bulin; Girgis Obaid; Zhiming Mai; Yan Baglo; Imran Rizvi; Tayyaba Hasan
Journal:  Biomaterials       Date:  2019-08-12       Impact factor: 12.479

6.  Hedgehog signaling mechanism and role in cancer.

Authors:  Jin Jiang
Journal:  Semin Cancer Biol       Date:  2021-04-06       Impact factor: 17.012

7.  Wild type and gain of function mutant TP53 can regulate the sensitivity of pancreatic cancer cells to chemotherapeutic drugs, EGFR/Ras/Raf/MEK, and PI3K/mTORC1/GSK-3 pathway inhibitors, nutraceuticals and alter metabolic properties.

Authors:  James A McCubrey; Akshaya K Meher; Shaw M Akula; Stephen L Abrams; Linda S Steelman; Michelle M LaHair; Richard A Franklin; Alberto M Martelli; Stefano Ratti; Lucio Cocco; Fulvio Barbaro; Przemysław Duda; Agnieszka Gizak
Journal:  Aging (Albany NY)       Date:  2022-04-27       Impact factor: 5.682

8.  Genotype tunes pancreatic ductal adenocarcinoma tissue tension to induce matricellular fibrosis and tumor progression.

Authors:  Hanane Laklai; Yekaterina A Miroshnikova; Michael W Pickup; Eric A Collisson; Grace E Kim; Alex S Barrett; Ryan C Hill; Johnathon N Lakins; David D Schlaepfer; Janna K Mouw; Valerie S LeBleu; Nilotpal Roy; Sergey V Novitskiy; Julia S Johansen; Valeria Poli; Raghu Kalluri; Christine A Iacobuzio-Donahue; Laura D Wood; Matthias Hebrok; Kirk Hansen; Harold L Moses; Valerie M Weaver
Journal:  Nat Med       Date:  2016-04-18       Impact factor: 53.440

9.  Senescence-Induced Vascular Remodeling Creates Therapeutic Vulnerabilities in Pancreas Cancer.

Authors:  Marcus Ruscetti; John P Morris; Riccardo Mezzadra; James Russell; Josef Leibold; Paul B Romesser; Janelle Simon; Amanda Kulick; Yu-Jui Ho; Myles Fennell; Jinyang Li; Robert J Norgard; John E Wilkinson; Direna Alonso-Curbelo; Ramya Sridharan; Daniel A Heller; Elisa de Stanchina; Ben Z Stanger; Charles J Sherr; Scott W Lowe
Journal:  Cell       Date:  2020-03-31       Impact factor: 41.582

Review 10.  Emerging concepts in pancreatic cancer medicine: targeting the tumor stroma.

Authors:  Albrecht Neesse; Sebastian Krug; Thomas M Gress; David A Tuveson; Patrick Michl
Journal:  Onco Targets Ther       Date:  2013-12-18       Impact factor: 4.147
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