PURPOSE: To compare the accuracy of liver fat quantification using chemical shift imaging (CSI) and H1 MR-spectroscopy (MRS) at 3.0 T in patients undergoing liver resection. METHODS: Totally 35 patients were included in this prospective IRB approved study. The histopathologically assessed liver fat was compared to the hepatic fat fractions calculated with CSI (with and without spleen correction) and MRS. Spearman's rank correlation and Fisher z-test were used for correlation analysis. Sensitivity and specificity regarding the detection of marked steatosis were calculated for the different modalities and compared using the McNemar test. RESULTS: MRS (r=.85) and CSI with spleen correction (r=.85) showed a significantly better correlation (p=.03) with histology compared to CSI without spleen correction (r=.67). Sensitivity and specificity for the detection of marked steatosis was 100% (12/12) and 87% (20/23) for MRS and 92% (11/12) and 83% (19/23) for CSI with spleen correction (p>.12). CONCLUSION: For the assessment of hepatic steatosis both CSI with spleen correction and MRS at 3.0 T, show a good correlation with histology. CSI without spleen correction should not be used. Sensitivity and specificity for the detection of marked steatosis are high with both modalities. However, results that are scattered around the cut-off values are not reliable enough for clinical decisions.
PURPOSE: To compare the accuracy of liver fat quantification using chemical shift imaging (CSI) and H1 MR-spectroscopy (MRS) at 3.0 T in patients undergoing liver resection. METHODS: Totally 35 patients were included in this prospective IRB approved study. The histopathologically assessed liver fat was compared to the hepatic fat fractions calculated with CSI (with and without spleen correction) and MRS. Spearman's rank correlation and Fisher z-test were used for correlation analysis. Sensitivity and specificity regarding the detection of marked steatosis were calculated for the different modalities and compared using the McNemar test. RESULTS:MRS (r=.85) and CSI with spleen correction (r=.85) showed a significantly better correlation (p=.03) with histology compared to CSI without spleen correction (r=.67). Sensitivity and specificity for the detection of marked steatosis was 100% (12/12) and 87% (20/23) for MRS and 92% (11/12) and 83% (19/23) for CSI with spleen correction (p>.12). CONCLUSION: For the assessment of hepatic steatosis both CSI with spleen correction and MRS at 3.0 T, show a good correlation with histology. CSI without spleen correction should not be used. Sensitivity and specificity for the detection of marked steatosis are high with both modalities. However, results that are scattered around the cut-off values are not reliable enough for clinical decisions.
Authors: Guido M Kukuk; Kanishka Hittatiya; Alois M Sprinkart; Holger Eggers; Jürgen Gieseke; Wolfgang Block; Philipp Moeller; Winfried A Willinek; Ulrich Spengler; Jonel Trebicka; Hans-Peter Fischer; Hans H Schild; Frank Träber Journal: Eur Radiol Date: 2015-04-23 Impact factor: 5.315
Authors: Joy Liau; Masoud Shiehmorteza; Olivier M Girard; Claude B Sirlin; Mark Bydder Journal: Magn Reson Imaging Date: 2013-04-18 Impact factor: 2.546
Authors: Yeon Hwa Yoo; Hak-Sun Kim; Young Han Lee; Choon-Sik Yoon; Mun Young Paek; Hanna Yoo; Stephan Kannengiesser; Tae-Sub Chung; Ho-Taek Song; Jin-Suck Suh; Sungjun Kim Journal: Korean J Radiol Date: 2015-08-21 Impact factor: 3.500