Literature DB >> 22770239

Polycomb in stem cells: PRC1 branches out.

Nuno Miguel Luis1, Lluis Morey, Luciano Di Croce, Salvador Aznar Benitah.   

Abstract

Polycomb group proteins (PcGs) generate chromatin-modifying complexes that regulate gene expression. PcGs are categorized into two major groups, polycomb repressive complex 1 (PRC1) and 2 (PRC2), which have classically been thought to function together. Here we discuss recent data challenging this model indicating that the distinct subunit composition of PRC1 confers specific and nonoverlapping functions in embryonic and adult stem cells.
Copyright © 2012 Elsevier Inc. All rights reserved.

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Year:  2012        PMID： 22770239     DOI： 10.1016/j.stem.2012.06.005

Source DB:  PubMed          Journal:  Cell Stem Cell        ISSN： 1875-9777            Impact factor:   24.633


  35 in total

1.  NDY1/KDM2B functions as a master regulator of polycomb complexes and controls self-renewal of breast cancer stem cells.

Authors:  Filippos Kottakis; Parthena Foltopoulou; Ioannis Sanidas; Patricia Keller; Ania Wronski; Benjamin T Dake; Scott A Ezell; Zhu Shen; Stephen P Naber; Philip W Hinds; Elizabeth McNiel; Charlotte Kuperwasser; Philip N Tsichlis
Journal:  Cancer Res       Date:  2014-05-22       Impact factor: 12.701

2.  Discovery and Characterization of a Cellular Potent Positive Allosteric Modulator of the Polycomb Repressive Complex 1 Chromodomain, CBX7.

Authors:  Kelsey N Lamb; Daniel Bsteh; Sarah N Dishman; Hagar F Moussa; Huitao Fan; Jacob I Stuckey; Jacqueline L Norris; Stephanie H Cholensky; Dongxu Li; Jingkui Wang; Cari Sagum; Benjamin Z Stanton; Mark T Bedford; Kenneth H Pearce; Terry P Kenakin; Dmitri B Kireev; Gang Greg Wang; Lindsey I James; Oliver Bell; Stephen V Frye
Journal:  Cell Chem Biol       Date:  2019-08-15       Impact factor: 8.116

3.  Essential Role for Polycomb Group Protein Pcgf6 in Embryonic Stem Cell Maintenance and a Noncanonical Polycomb Repressive Complex 1 (PRC1) Integrity.

Authors:  Wukui Zhao; Huan Tong; Yikai Huang; Yun Yan; Huajian Teng; Yin Xia; Qing Jiang; Jinzhong Qin
Journal:  J Biol Chem       Date:  2017-01-03       Impact factor: 5.157

4.  Dual role of Med12 in PRC1-dependent gene repression and ncRNA-mediated transcriptional activation.

Authors:  Thaleia Papadopoulou; Aysegül Kaymak; Sergi Sayols; Holger Richly
Journal:  Cell Cycle       Date:  2016-04-20       Impact factor: 4.534

Review 5.  Epigenetic regulations through DNA methylation and hydroxymethylation: clues for early pregnancy in decidualization.

Authors:  Fei Gao; Sanjoy K Das
Journal:  Biomol Concepts       Date:  2014-05

6.  Variable requirements for DNA-binding proteins at polycomb-dependent repressive regions in human HOX clusters.

Authors:  Caroline J Woo; Peter V Kharchenko; Laurence Daheron; Peter J Park; Robert E Kingston
Journal:  Mol Cell Biol       Date:  2013-06-17       Impact factor: 4.272

7.  Inhibition of PRC2 histone methyltransferase activity increases TRAIL-mediated apoptosis sensitivity in human colon cancer cells.

Authors:  Yannick D Benoit; Kristian B Laursen; Mavee S Witherspoon; Steven M Lipkin; Lorraine J Gudas
Journal:  J Cell Physiol       Date:  2013-04       Impact factor: 6.384

Review 8.  Polycomb group proteins and MYC: the cancer connection.

Authors:  Leonidas Benetatos; George Vartholomatos; Eleftheria Hatzimichael
Journal:  Cell Mol Life Sci       Date:  2013-07-30       Impact factor: 9.261

9.  Epigenetic control of natural killer cell maturation by histone H2A deubiquitinase, MYSM1.

Authors:  Vijayalakshmi Nandakumar; Yuchia Chou; Linda Zang; Xue F Huang; Si-Yi Chen
Journal:  Proc Natl Acad Sci U S A       Date:  2013-09-23       Impact factor: 11.205

10.  Polycomb group RING finger proteins 3/5 activate transcription via an interaction with the pluripotency factor Tex10 in embryonic stem cells.

Authors:  Wukui Zhao; Yikai Huang; Jingzi Zhang; Mengjie Liu; Haijing Ji; Congcong Wang; Ning Cao; Chaojun Li; Yin Xia; Qing Jiang; Jinzhong Qin
Journal:  J Biol Chem       Date:  2017-10-20       Impact factor: 5.157
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