Literature DB >> 22770236

An old drug for new ideas: metformin promotes adult neurogenesis and spatial memory formation.

Matthew B Potts1, Daniel A Lim.   

Abstract

Identifying well-tolerated, oral medications that enhance adult neurogenesis is of great clinical interest. In this issue of Cell Stem Cell, Wang et al. (2012) demonstrate that the diabetes medication metformin enhances spatial learning in mice by activating the atypical PKC/CBP pathway in adult neural stem cells.
Copyright © 2012 Elsevier Inc. All rights reserved.

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Year:  2012        PMID： 22770236      PMCID： PMC3468946          DOI： 10.1016/j.stem.2012.06.003

Source DB:  PubMed          Journal:  Cell Stem Cell        ISSN： 1875-9777            Impact factor:   24.633


  10 in total

1.  Metformin activates an atypical PKC-CBP pathway to promote neurogenesis and enhance spatial memory formation.

Authors:  Jing Wang; Denis Gallagher; Loren M DeVito; Gonzalo I Cancino; David Tsui; Ling He; Gordon M Keller; Paul W Frankland; David R Kaplan; Freda D Miller
Journal:  Cell Stem Cell       Date:  2012-07-06       Impact factor: 24.633

Review 2.  Bioenergy sensing in the brain: the role of AMP-activated protein kinase in neuronal metabolism, development and neurological diseases.

Authors:  Stephen Amato; Heng-Ye Man
Journal:  Cell Cycle       Date:  2011-10-15       Impact factor: 4.534

Review 3.  Adult neurogenesis and repair of the adult CNS with neural progenitors, precursors, and stem cells.

Authors:  Jason G Emsley; Bartley D Mitchell; Gerd Kempermann; Jeffrey D Macklis
Journal:  Prog Neurobiol       Date:  2005-04       Impact factor: 11.685

Review 4.  Adult neurogenesis in the mammalian brain: significant answers and significant questions.

Authors:  Guo-Li Ming; Hongjun Song
Journal:  Neuron       Date:  2011-05-26       Impact factor: 17.173

Review 5.  New neurons and new memories: how does adult hippocampal neurogenesis affect learning and memory?

Authors:  Wei Deng; James B Aimone; Fred H Gage
Journal:  Nat Rev Neurosci       Date:  2010-03-31       Impact factor: 34.870

6.  CBP histone acetyltransferase activity regulates embryonic neural differentiation in the normal and Rubinstein-Taybi syndrome brain.

Authors:  Jing Wang; Ian C G Weaver; Andrée Gauthier-Fisher; Haoran Wang; Ling He; John Yeomans; Frederic Wondisford; David R Kaplan; Freda D Miller
Journal:  Dev Cell       Date:  2010-01-19       Impact factor: 12.270

7.  Histone deacetylase inhibition-mediated neuronal differentiation of multipotent adult neural progenitor cells.

Authors:  Jenny Hsieh; Kinichi Nakashima; Tomoko Kuwabara; Eunice Mejia; Fred H Gage
Journal:  Proc Natl Acad Sci U S A       Date:  2004-11-10       Impact factor: 11.205

8.  Discovery of a proneurogenic, neuroprotective chemical.

Authors:  Andrew A Pieper; Shanhai Xie; Emanuela Capota; Sandi Jo Estill; Jeannie Zhong; Jeffrey M Long; Ginger L Becker; Paula Huntington; Shauna E Goldman; Ching-Han Shen; Maria Capota; Jeremiah K Britt; Tiina Kotti; Kerstin Ure; Daniel J Brat; Noelle S Williams; Karen S MacMillan; Jacinth Naidoo; Lisa Melito; Jenny Hsieh; Jef De Brabander; Joseph M Ready; Steven L McKnight
Journal:  Cell       Date:  2010-07-09       Impact factor: 41.582

9.  Metformin and insulin suppress hepatic gluconeogenesis through phosphorylation of CREB binding protein.

Authors:  Ling He; Amin Sabet; Stephen Djedjos; Ryan Miller; Xiaojian Sun; Mehboob A Hussain; Sally Radovick; Fredric E Wondisford
Journal:  Cell       Date:  2009-05-15       Impact factor: 41.582

10.  Chromatin acetylation, memory, and LTP are impaired in CBP+/- mice: a model for the cognitive deficit in Rubinstein-Taybi syndrome and its amelioration.

Authors:  Juan M Alarcón; Gaël Malleret; Khalid Touzani; Svetlana Vronskaya; Shunsuke Ishii; Eric R Kandel; Angel Barco
Journal:  Neuron       Date:  2004-06-24       Impact factor: 17.173
  10 in total
  19 in total

Review 1.  ADULT NEUROGENESIS IN HUMANS: A Review of Basic Concepts, History, Current Research, and Clinical Implications.

Authors:  Ashutosh Kumar; Vikas Pareek; Muneeb A Faiq; Sanjib K Ghosh; Chiman Kumari
Journal:  Innov Clin Neurosci       Date:  2019-05-01

Review 2.  Neurogenesis in Stroke Recovery.

Authors:  Seong-Ho Koh; Hyun-Hee Park
Journal:  Transl Stroke Res       Date:  2016-03-18       Impact factor: 6.829

Review 3.  Drugs and Endogenous Factors as Protagonists in Neurogenic Stimulation.

Authors:  Raphaela A Chiareli; Bruno L Marques; Gustavo A de Carvalho; Raysa T V de Souza; Pedro H G Santana; Helton C Santiago; Mauro C X Pinto; Alexander Birbrair; Ricardo C Parreira; Henning Ulrich; Rodrigo R Resende
Journal:  Stem Cell Rev Rep       Date:  2022-08-12       Impact factor: 6.692

4.  Harnessing neurogenesis in the adult brain-A role in type 2 diabetes mellitus and Alzheimer's disease.

Authors:  Orly Lazarov; Richard D Minshall; Marcelo G Bonini
Journal:  Int Rev Neurobiol       Date:  2020       Impact factor: 3.230

5.  Metformin Prevented Dopaminergic Neurotoxicity Induced by 3,4-Methylenedioxymethamphetamine Administration.

Authors:  Pier Francesca Porceddu; Ismail Ogunbayode Ishola; Liliana Contu; Micaela Morelli
Journal:  Neurotox Res       Date:  2016-06-01       Impact factor: 3.911

Review 6.  Metformin and cognition from the perspectives of sex, age, and disease.

Authors:  Kiran Chaudhari; Conner D Reynolds; Shao-Hua Yang
Journal:  Geroscience       Date:  2020-01-02       Impact factor: 7.713

7.  Chronic metformin treatment improves post-stroke angiogenesis and recovery after experimental stroke.

Authors:  Venugopal R Venna; Jun Li; Matthew D Hammond; Nickolas S Mancini; Louise D McCullough
Journal:  Eur J Neurosci       Date:  2014-03-21       Impact factor: 3.386

8.  Metformin attenuates blood-brain barrier disruption in mice following middle cerebral artery occlusion.

Authors:  Yanqun Liu; Guanghui Tang; Yaning Li; Yang Wang; Xiaoyan Chen; Xiang Gu; Zhijun Zhang; Yongting Wang; Guo-Yuan Yang
Journal:  J Neuroinflammation       Date:  2014-10-15       Impact factor: 8.322

Review 9.  Parkinson's disease between internal medicine and neurology.

Authors:  Ilona Csoti; Wolfgang H Jost; Heinz Reichmann
Journal:  J Neural Transm (Vienna)       Date:  2015-08-23       Impact factor: 3.575

10.  Cerium oxide nanoparticles promote neurogenesis and abrogate hypoxia-induced memory impairment through AMPK-PKC-CBP signaling cascade.

Authors:  Aditya Arya; Anamika Gangwar; Sushil Kumar Singh; Manas Roy; Mainak Das; Niroj Kumar Sethy; Kalpana Bhargava
Journal:  Int J Nanomedicine       Date:  2016-03-23
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