Literature DB >> 22767575

Coagulopathy in APL: a step forward?

Giuseppe Avvisati1.   

Abstract

Jácomo and colleagues advance our understanding of the coagulopathy present in acute promyelocytic leukemia (APL). By means of elegant and intriguing experiments performed in an APL mouse model, they demonstrate that supplementation with L-methionine, an essential amino acid that assists in the metabolism of homocysteine (Hcy), is able to prevent the fibrinolytic abnormalities present in this leukemia.(1)

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Year:  2012        PMID: 22767575     DOI: 10.1182/blood-2012-05-427427

Source DB:  PubMed          Journal:  Blood        ISSN: 0006-4971            Impact factor:   22.113


  5 in total

1.  Stepwise discriminant function analysis for rapid identification of acute promyelocytic leukemia from acute myeloid leukemia with multiparameter flow cytometry.

Authors:  Zhanguo Chen; Yan Li; Yongqing Tong; Qingping Gao; Xiaolu Mao; Wenjing Zhang; Zunen Xia; Chaohong Fu
Journal:  Int J Hematol       Date:  2016-01-12       Impact factor: 2.490

2.  Risk Markers for Significant Bleeding and Thrombosis in Pediatric Acute Promyelocytic Leukemia; Report From the Children's Oncology Group Study AAML0631.

Authors:  Madhvi Rajpurkar; Todd A Alonzo; Yi-Cheng Wang; Robert B Gerbing; Alan S Gamis; James H Feusner; John Gregory; Matthew A Kutny
Journal:  J Pediatr Hematol Oncol       Date:  2019-01       Impact factor: 1.289

Review 3.  Bleeding Disorders in Primary Fibrinolysis.

Authors:  Massimo Franchini; Marco Zaffanello; Pier Mannuccio Mannucci
Journal:  Int J Mol Sci       Date:  2021-06-29       Impact factor: 5.923

4.  Asphyxia by Drowning Induces Massive Bleeding Due To Hyperfibrinolytic Disseminated Intravascular Coagulation.

Authors:  Michael Schwameis; Andreas Schober; Christian Schörgenhofer; Wolfgang Reinhard Sperr; Herbert Schöchl; Karin Janata-Schwatczek; Erol Istepan Kürkciyan; Fritz Sterz; Bernd Jilma
Journal:  Crit Care Med       Date:  2015-11       Impact factor: 7.598

5.  Metabolomics Reveals that Cysteine Metabolism Plays a Role in Celastrol-Induced Mitochondrial Apoptosis in HL-60 and NB-4 Cells.

Authors:  Minjian Chen; Jing Yang; Lei Li; Yanhui Hu; Xiaomei Lu; Rongli Sun; Yubang Wang; Xinru Wang; Xiaoling Zhang
Journal:  Sci Rep       Date:  2020-01-16       Impact factor: 4.379

  5 in total

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