Role of microRNAs in peripheral artery disease (review).

Peripheral arterial disease (PAD) involves a general vascular problem of diffuse atherosclerosis. The key pathological process is characterized by the aberrant proliferation of vascular smooth muscle cells and the formation of neointimal lesions. The molecular mechanisms involved in the regulation of the occurrence and development of PAD remain unclear. microRNAs (miRNAs) are highly conserved 20-25 nt-long non-coding RNAs that negatively regulate gene expression. Recent evidence has demonstrated that specific miRNAs are involved in the pathological processes of PAD, and these miRNAs are found to be critical modulators of vascular cell functions, including cell differentiation, contraction, migration, proliferation and apoptosis. This review summarizes findings of studies regarding the roles of specific miRNAs in PAD.