BACKGROUND: Obesity in childhood and adolescence has important health consequences, but its relation to risk of adult depression remains uncertain. OBJECTIVE: To examine the effect of perceived and actual obesity during childhood and adolescence on prevalence and incidence of adult depression risk. METHODS: Cohort study of 91,798 female registered nurses followed longitudinally for 12 years. RESULTS: As compared with lean women of the same age, women in the two highest categories of body shape at age 10 had both higher prevalence (OR=2.59, 95% CI 1.46 to 4.61) and incidence (OR=2.01, 95% CI 1.08 to 3.71) of depression. Similar results were obtained for body shape at age 20 (OR=3.43 for prevalence and OR=2.03 for incidence) and for body mass index (BMI) at age 18 (OR=2.92 for BMI ≥ 40 kg/m(2)). These associations remained significant after adjustment for multiple confounders. CONCLUSION: These results indicate that childhood-adolescence obesity is a strong and independent risk factor for adult depression.
BACKGROUND:Obesity in childhood and adolescence has important health consequences, but its relation to risk of adult depression remains uncertain. OBJECTIVE: To examine the effect of perceived and actual obesity during childhood and adolescence on prevalence and incidence of adult depression risk. METHODS: Cohort study of 91,798 female registered nurses followed longitudinally for 12 years. RESULTS: As compared with lean women of the same age, women in the two highest categories of body shape at age 10 had both higher prevalence (OR=2.59, 95% CI 1.46 to 4.61) and incidence (OR=2.01, 95% CI 1.08 to 3.71) of depression. Similar results were obtained for body shape at age 20 (OR=3.43 for prevalence and OR=2.03 for incidence) and for body mass index (BMI) at age 18 (OR=2.92 for BMI ≥ 40 kg/m(2)). These associations remained significant after adjustment for multiple confounders. CONCLUSION: These results indicate that childhood-adolescence obesity is a strong and independent risk factor for adult depression.
Authors: April Opoliner; Jenny L Carwile; Deborah Blacker; Garrett M Fitzmaurice; S Bryn Austin Journal: Arch Womens Ment Health Date: 2014-07-22 Impact factor: 3.633
Authors: Jessica Tyrrell; Anwar Mulugeta; Andrew R Wood; Ang Zhou; Robin N Beaumont; Marcus A Tuke; Samuel E Jones; Katherine S Ruth; Hanieh Yaghootkar; Seth Sharp; William D Thompson; Yingjie Ji; Jamie Harrison; Rachel M Freathy; Anna Murray; Michael N Weedon; Cathryn Lewis; Timothy M Frayling; Elina Hyppönen Journal: Int J Epidemiol Date: 2019-06-01 Impact factor: 7.196