BACKGROUND: Colorectal cancer is the third most common cancer in Australia. The median overall survival for metastatic colorectal cancer is nearly 2 years. However, there may be survival differences based on site of metastatic disease. METHODS: Data was collected from the South Australian Registry for Advanced Colorectal Cancer. A total of 1207 patients with single site metastatic disease at initial diagnosis were subclassified into 6 subgroups: liver only (n = 780), pelvic only (n = 148), lung only (n = 142), lymph node only (n = 95), bone only (n = 32), and brain only (n = 10). Univariate and multivariate parametric survival analyses were performed. RESULTS: Median overall survival was 20.3 months for the whole group. The overall survival for lung-only metastases group was 41.1 months followed by liver- and pelvic-only disease groups (22.8 and 23.8 months, respectively). Patients with isolated bone-only and brain-only metastases had poor overall survival (5.1 and 5.7 months, respectively). On multivariate analysis, prognosis was superior for the lung-only group. CONCLUSIONS: Lung only group had the longest median overall survival. Bone and brain sites had a poor outlook. Site of metastatic disease at initial presentation may be prognostic.
BACKGROUND:Colorectal cancer is the third most common cancer in Australia. The median overall survival for metastatic colorectal cancer is nearly 2 years. However, there may be survival differences based on site of metastatic disease. METHODS: Data was collected from the South Australian Registry for Advanced Colorectal Cancer. A total of 1207 patients with single site metastatic disease at initial diagnosis were subclassified into 6 subgroups: liver only (n = 780), pelvic only (n = 148), lung only (n = 142), lymph node only (n = 95), bone only (n = 32), and brain only (n = 10). Univariate and multivariate parametric survival analyses were performed. RESULTS: Median overall survival was 20.3 months for the whole group. The overall survival for lung-only metastases group was 41.1 months followed by liver- and pelvic-only disease groups (22.8 and 23.8 months, respectively). Patients with isolated bone-only and brain-only metastases had poor overall survival (5.1 and 5.7 months, respectively). On multivariate analysis, prognosis was superior for the lung-only group. CONCLUSIONS: Lung only group had the longest median overall survival. Bone and brain sites had a poor outlook. Site of metastatic disease at initial presentation may be prognostic.
Authors: Lydia G M van der Geest; Jorine't Lam-Boer; Miriam Koopman; Cees Verhoef; Marloes A G Elferink; Johannes H W de Wilt Journal: Clin Exp Metastasis Date: 2015-04-22 Impact factor: 5.150
Authors: Jashodeep Datta; J Joshua Smith; Walid K Chatila; John C McAuliffe; Cyriac Kandoth; Efsevia Vakiani; Timothy L Frankel; Karuna Ganesh; Isaac Wasserman; Marla Lipsyc-Sharf; Jose Guillem; Garrett M Nash; Philip B Paty; Martin R Weiser; Leonard B Saltz; Michael F Berger; William R Jarnagin; Vinod Balachandran; T Peter Kingham; Nancy E Kemeny; Andrea Cercek; Julio Garcia-Aguilar; Barry S Taylor; Agnes Viale; Rona Yaeger; David B Solit; Nikolaus Schultz; Michael I D'Angelica Journal: Clin Cancer Res Date: 2019-11-12 Impact factor: 12.531
Authors: Yvette Hm Claassen; Maxime Jm van der Valk; Anne J Breugom; Martine A Frouws; Esther Bastiaannet; Gerrit-Jan Liefers; Cornelis Jh van de Velde; Ellen Kapiteijn Journal: Cochrane Database Syst Rev Date: 2018-11-21