PURPOSE: We modeled the age-related trajectory of glucose and determined whether cardiorespiratory fitness altered the trajectory in a cohort of men from the Aerobics Center Longitudinal Study. METHODS: A total of 10,092 men free of diagnosed diabetes, cardiovascular disease, and cancer, ages 20 to 90 years, completed from 2 to 21 health examinations between 1977 and 2005. Cardiorespiratory fitness was measured by a maximal treadmill exercise test and normalized for age. The covariates included waist circumference, hypertension, elevated cholesterol, smoking behavior, and physical activity. RESULTS: Linear mixed models regression analysis showed that fasting glucose increased at a linear rate with aging. Glucose increased at a yearly rate of 0.17 mg/dL (95% confidence interval: 0.16-0.19). Fitness had little influence on the aging glucose trajectory below age 35, but significantly influenced the trend after age 35 (P for interaction < .001). The aging-related glucose increases in low-fitness men (0.25 mg/dL per year) was greater than average-fitness (0.15 mg/dL per year) and high-fitness (0.13 mg/dL per year) men. CONCLUSIONS: The aging-related fasting glucose increases in low-fitness men was nearly double that of high-fitness men. Our results may suggest that it is possible to delay the age-related glucose impairment through increasing one's fitness level.
PURPOSE: We modeled the age-related trajectory of glucose and determined whether cardiorespiratory fitness altered the trajectory in a cohort of men from the Aerobics Center Longitudinal Study. METHODS: A total of 10,092 men free of diagnosed diabetes, cardiovascular disease, and cancer, ages 20 to 90 years, completed from 2 to 21 health examinations between 1977 and 2005. Cardiorespiratory fitness was measured by a maximal treadmill exercise test and normalized for age. The covariates included waist circumference, hypertension, elevated cholesterol, smoking behavior, and physical activity. RESULTS: Linear mixed models regression analysis showed that fasting glucose increased at a linear rate with aging. Glucose increased at a yearly rate of 0.17 mg/dL (95% confidence interval: 0.16-0.19). Fitness had little influence on the aging glucose trajectory below age 35, but significantly influenced the trend after age 35 (P for interaction < .001). The aging-related glucose increases in low-fitnessmen (0.25 mg/dL per year) was greater than average-fitness (0.15 mg/dL per year) and high-fitness (0.13 mg/dL per year) men. CONCLUSIONS: The aging-related fasting glucose increases in low-fitnessmen was nearly double that of high-fitness men. Our results may suggest that it is possible to delay the age-related glucose impairment through increasing one's fitness level.
Authors: Yong-Moon Mark Park; Xuemei Sui; Junxiu Liu; Haiming Zhou; Peter F Kokkinos; Carl J Lavie; James W Hardin; Steven N Blair Journal: J Am Coll Cardiol Date: 2015-05-19 Impact factor: 24.094
Authors: Junxiu Liu; Xuemei Sui; Carl J Lavie; Haiming Zhou; Yong-Moon Mark Park; Bo Cai; Jihong Liu; Steven N Blair Journal: J Am Coll Cardiol Date: 2014-09-23 Impact factor: 24.094