Yonghong Zhang1, Yong Xiang, Jin Liu. 1. Department of Anesthesiology, West China Hospital, Sichuan University, Chengdu, Sichuan Province, China 610041.
Abstract
STUDY OBJECTIVE: To compare the efficacy of pretreatment with parecoxib and lidocaine to prevent rocuronium injection pain. DESIGN: Prospective, randomized, double-blinded study. SETTING: Academic medical center. PATIENTS: 160 adult ASA physical status 1 and 2 patients scheduled for elective surgery. INTERVENTIONS: Patients were randomly allocated to 4 groups of 40 patients each to receive pretreatment with normal saline (Group C), parecoxib 20 mg (Group P(20)), parecoxib 40 mg (Group P(40)), or lidocaine 40 mg (Group L). All groups underwent venous occlusion for two minutes before rocuronium was injected. MEASUREMENTS: Pain scores were obtained by a study-blinded observer immediately after the pretreatment. MAIN RESULTS: The frequency of rocuronium injection pain in the saline group (80%) was significantly higher than in Group P(20) (55%), Group P(40) (20%), and Group L (25%) (P < 0.05). The frequency and intensity of rocuronium-induced pain were statistically similar between Group P(40) and Group L. In the parecoxib 40 mg and lidocaine 40 mg groups, the frequency of pain was significantly less than in the parecoxib 20 mg group (P < 0.05). CONCLUSION: Pretreatment with parecoxib and lidocaine was effective in reducing the frequency and severity of pain with rocuronium injection whereas pretreatment with parecoxib 40 mg and lidocaine 40 mg were the most effective treatments.
RCT Entities:
STUDY OBJECTIVE: To compare the efficacy of pretreatment with parecoxib and lidocaine to prevent rocuronium injection pain. DESIGN: Prospective, randomized, double-blinded study. SETTING: Academic medical center. PATIENTS: 160 adult ASA physical status 1 and 2 patients scheduled for elective surgery. INTERVENTIONS:Patients were randomly allocated to 4 groups of 40 patients each to receive pretreatment with normal saline (Group C), parecoxib 20 mg (Group P(20)), parecoxib 40 mg (Group P(40)), or lidocaine 40 mg (Group L). All groups underwent venous occlusion for two minutes before rocuronium was injected. MEASUREMENTS: Pain scores were obtained by a study-blinded observer immediately after the pretreatment. MAIN RESULTS: The frequency of rocuronium injection pain in the saline group (80%) was significantly higher than in Group P(20) (55%), Group P(40) (20%), and Group L (25%) (P < 0.05). The frequency and intensity of rocuronium-induced pain were statistically similar between Group P(40) and Group L. In the parecoxib 40 mg and lidocaine 40 mg groups, the frequency of pain was significantly less than in the parecoxib 20 mg group (P < 0.05). CONCLUSION: Pretreatment with parecoxib and lidocaine was effective in reducing the frequency and severity of pain with rocuronium injection whereas pretreatment with parecoxib 40 mg and lidocaine 40 mg were the most effective treatments.
Authors: Ki Tae Jung; Hye Ji Kim; Hyo Sung Bae; Hyun Young Lee; Sang Hun Kim; Keum Young So; Kyung Jun Lim; Byung Sik Yu; Jong Dal Jung; Tae Hun An; Hong Chan Park Journal: Korean J Anesthesiol Date: 2014-09-24