BACKGROUND: Higher cognitive dysfunction, lower perceptual disturbance and its relation to the structures that implicate such processes have been considered as key features in patients with schizophrenia. However, little is known about the relationship between perceptual processing and structural deficits in ultra-high-risk for psychosis. METHODS: We investigated the dipole moment of M100 auditory evoked response using a magnetoencephalography in 18 patients with schizophrenia, 16 ultra-high-risk for psychosis and 16 healthy controls, and their relation to cortical thinning on Heschl's gyrus and planum temporale. RESULTS: The auditory evoked M100 dipole moment was decreased in the ultra-high-risk subjects and in the patients with schizophrenia. Ultra-high-risk subjects showed impaired right M100 dipole magnitude, similar to patients with schizophrenia. Robust correlations between the cortical thickness of left Heschl's gyrus and the left M100 dipole moment were found in patients with schizophrenia. Moreover, correlations were also evident between right Heschl's gyrus and right M100 in subjects at ultra-high-risk for psychosis. CONCLUSIONS: The primary feature of auditory perception in ultra-high-risk subjects and schizophrenia patients is an encoding deficit that manifests as a reduced M100 dipole moment. The relationship between abnormal M100, thinning of cortical generators and their symptomatology were shown to exist prior to the onset of overt psychosis and progressively worsen over time. Therefore, they may be a potential indicator of the development of schizophrenia.
BACKGROUND: Higher cognitive dysfunction, lower perceptual disturbance and its relation to the structures that implicate such processes have been considered as key features in patients with schizophrenia. However, little is known about the relationship between perceptual processing and structural deficits in ultra-high-risk for psychosis. METHODS: We investigated the dipole moment of M100 auditory evoked response using a magnetoencephalography in 18 patients with schizophrenia, 16 ultra-high-risk for psychosis and 16 healthy controls, and their relation to cortical thinning on Heschl's gyrus and planum temporale. RESULTS: The auditory evoked M100 dipole moment was decreased in the ultra-high-risk subjects and in the patients with schizophrenia. Ultra-high-risk subjects showed impaired right M100 dipole magnitude, similar to patients with schizophrenia. Robust correlations between the cortical thickness of left Heschl's gyrus and the left M100 dipole moment were found in patients with schizophrenia. Moreover, correlations were also evident between right Heschl's gyrus and right M100 in subjects at ultra-high-risk for psychosis. CONCLUSIONS: The primary feature of auditory perception in ultra-high-risk subjects and schizophreniapatients is an encoding deficit that manifests as a reduced M100 dipole moment. The relationship between abnormal M100, thinning of cortical generators and their symptomatology were shown to exist prior to the onset of overt psychosis and progressively worsen over time. Therefore, they may be a potential indicator of the development of schizophrenia.
Authors: Theo G M van Erp; Esther Walton; Derrek P Hibar; Lianne Schmaal; Wenhao Jiang; David C Glahn; Godfrey D Pearlson; Nailin Yao; Masaki Fukunaga; Ryota Hashimoto; Naohiro Okada; Hidenaga Yamamori; Juan R Bustillo; Vincent P Clark; Ingrid Agartz; Bryon A Mueller; Wiepke Cahn; Sonja M C de Zwarte; Hilleke E Hulshoff Pol; René S Kahn; Roel A Ophoff; Neeltje E M van Haren; Ole A Andreassen; Anders M Dale; Nhat Trung Doan; Tiril P Gurholt; Cecilie B Hartberg; Unn K Haukvik; Kjetil N Jørgensen; Trine V Lagerberg; Ingrid Melle; Lars T Westlye; Oliver Gruber; Bernd Kraemer; Anja Richter; David Zilles; Vince D Calhoun; Benedicto Crespo-Facorro; Roberto Roiz-Santiañez; Diana Tordesillas-Gutiérrez; Carmel Loughland; Vaughan J Carr; Stanley Catts; Vanessa L Cropley; Janice M Fullerton; Melissa J Green; Frans A Henskens; Assen Jablensky; Rhoshel K Lenroot; Bryan J Mowry; Patricia T Michie; Christos Pantelis; Yann Quidé; Ulrich Schall; Rodney J Scott; Murray J Cairns; Marc Seal; Paul A Tooney; Paul E Rasser; Gavin Cooper; Cynthia Shannon Weickert; Thomas W Weickert; Derek W Morris; Elliot Hong; Peter Kochunov; Lauren M Beard; Raquel E Gur; Ruben C Gur; Theodore D Satterthwaite; Daniel H Wolf; Aysenil Belger; Gregory G Brown; Judith M Ford; Fabio Macciardi; Daniel H Mathalon; Daniel S O'Leary; Steven G Potkin; Adrian Preda; James Voyvodic; Kelvin O Lim; Sarah McEwen; Fude Yang; Yunlong Tan; Shuping Tan; Zhiren Wang; Fengmei Fan; Jingxu Chen; Hong Xiang; Shiyou Tang; Hua Guo; Ping Wan; Dong Wei; Henry J Bockholt; Stefan Ehrlich; Rick P F Wolthusen; Margaret D King; Jody M Shoemaker; Scott R Sponheim; Lieuwe De Haan; Laura Koenders; Marise W Machielsen; Therese van Amelsvoort; Dick J Veltman; Francesca Assogna; Nerisa Banaj; Pietro de Rossi; Mariangela Iorio; Fabrizio Piras; Gianfranco Spalletta; Peter J McKenna; Edith Pomarol-Clotet; Raymond Salvador; Aiden Corvin; Gary Donohoe; Sinead Kelly; Christopher D Whelan; Erin W Dickie; David Rotenberg; Aristotle N Voineskos; Simone Ciufolini; Joaquim Radua; Paola Dazzan; Robin Murray; Tiago Reis Marques; Andrew Simmons; Stefan Borgwardt; Laura Egloff; Fabienne Harrisberger; Anita Riecher-Rössler; Renata Smieskova; Kathryn I Alpert; Lei Wang; Erik G Jönsson; Sanne Koops; Iris E C Sommer; Alessandro Bertolino; Aurora Bonvino; Annabella Di Giorgio; Emma Neilson; Andrew R Mayer; Julia M Stephen; Jun Soo Kwon; Je-Yeon Yun; Dara M Cannon; Colm McDonald; Irina Lebedeva; Alexander S Tomyshev; Tolibjohn Akhadov; Vasily Kaleda; Helena Fatouros-Bergman; Lena Flyckt; Geraldo F Busatto; Pedro G P Rosa; Mauricio H Serpa; Marcus V Zanetti; Cyril Hoschl; Antonin Skoch; Filip Spaniel; David Tomecek; Saskia P Hagenaars; Andrew M McIntosh; Heather C Whalley; Stephen M Lawrie; Christian Knöchel; Viola Oertel-Knöchel; Michael Stäblein; Fleur M Howells; Dan J Stein; Henk S Temmingh; Anne Uhlmann; Carlos Lopez-Jaramillo; Danai Dima; Agnes McMahon; Joshua I Faskowitz; Boris A Gutman; Neda Jahanshad; Paul M Thompson; Jessica A Turner Journal: Biol Psychiatry Date: 2018-05-14 Impact factor: 12.810