Literature DB >> 227587

Relationship between inhibition of protein methylase I and inhibition of Rous sarcoma virus-induced cell transformation.

J Enouf, F Lawrence, C Tempete, M Robert-Gero, E Lederer.   

Abstract

A correlation was found between inhibition of protein methylase I and inhibition of virus-induced cell transformation by structural analogs of S-adenosylhomocysteine; all good inhibitors of this enzyme are also good inhibitors of Rous sarcoma virus-induced chicke embryo fibroblast transformation. The inhibitory effect of these analogs was similar on enzymes from normal and transformed cells; no significant variation of the inhibition constants was observed after purification of protein methylase I. From the kinetic constants obtained, a structure-activity relationship can be established for protein methylase I.

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Year:  1979        PMID： 227587

Source DB:  PubMed          Journal:  Cancer Res        ISSN： 0008-5472            Impact factor:   12.701


  10 in total

1.  Tyrosine kinase activity coupled to the high-affinity nerve growth factor-receptor complex.

Authors:  S O Meakin; E M Shooter
Journal:  Proc Natl Acad Sci U S A       Date:  1991-07-01       Impact factor: 11.205

2.  Growth and metastases of human lung cancer are inhibited in mouse xenografts by a transition state analogue of 5'-methylthioadenosine phosphorylase.

Authors:  Indranil Basu; Joseph Locker; Maria B Cassera; Thomas J Belbin; Emilio F Merino; Xinyuan Dong; Ivan Hemeon; Gary B Evans; Chandan Guha; Vern L Schramm
Journal:  J Biol Chem       Date:  2010-12-06       Impact factor: 5.157

3.  Effect of 5'-deoxy-5'-isobutylthioadenosine on putrescine uptake and polyamine biosynthesis by chick embryo fibroblasts.

Authors:  F Lawrence; U Bachrach; M Robert-Géro
Journal:  Biochem J       Date:  1982-06-15       Impact factor: 3.857

4.  Effect of several inhibitors of enzymatic DNA methylation on the in vivo methylation of different classes of DNA sequences in a cultured human cell line.

Authors:  D M Woodcock; J K Adams; R G Allan; I A Cooper
Journal:  Nucleic Acids Res       Date:  1983-01-25       Impact factor: 16.971

5.  Nerve growth factor induces protein-tyrosine phosphorylation.

Authors:  P A Maher
Journal:  Proc Natl Acad Sci U S A       Date:  1988-09       Impact factor: 11.205

6.  Cyclic AMP-mediated control of meiosis: effects of progesterone, cholera toxin, and membrane-active drugs in Xenopus laevis oocytes.

Authors:  S Schorderet-Slatkine; M Schorderet; E E Baulieu
Journal:  Proc Natl Acad Sci U S A       Date:  1982-02       Impact factor: 11.205

7.  Association of SIBA treatment and a Met-depleted diet inhibits in vitro growth and in vivo metastatic spread of experimental tumor cell lines.

Authors:  F Breillout; M F Poupon; P Blanchard; V Lascaux; P Echinard-Garin; M Robert-Gero
Journal:  Clin Exp Metastasis       Date:  1988 Jan-Feb       Impact factor: 5.150

8.  Effect of analogues of 5'-methylthioadenosine on cellular metabolism. Inactivation of S-adenosylhomocysteine hydrolase by 5'-isobutylthioadenosine.

Authors:  F Della Ragione; A E Pegg
Journal:  Biochem J       Date:  1983-02-15       Impact factor: 3.857

9.  Arginine Methyltransferases Are Regulated by Epstein-Barr Virus in B Cells and Are Differentially Expressed in Hodgkin's Lymphoma.

Authors:  Sarah Leonard; Naheema Gordon; Nikki Smith; Martin Rowe; Paul G Murray; Ciarán B Woodman
Journal:  Pathogens       Date:  2012-09-19

10.  Differential inhibition of nerve growth factor and epidermal growth factor effects on the PC12 pheochromocytoma line.

Authors:  P J Seeley; A Rukenstein; J L Connolly; L A Greene
Journal:  J Cell Biol       Date:  1984-02       Impact factor: 10.539
  10 in total

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