Literature DB >> 22753968

Presumed case of "stiff-horse syndrome" caused by decreased gamma-aminobutyric acid (GABA) production in an American Paint mare.

Tawna Backman Purcell1, Ann Davidson Sellers, Lutz S Goehring.   

Abstract

Glutamic acid decarboxylase (GAD) converts glutamic acid into the inhibitory neurotransmitter γ-aminobutyric acid (GABA). Increased serum GAD (auto) antibody concentrations were found in a mare with increased postural musculature tone resulting in stiffness and recumbence. The mare was treated with dexamethasone which resulted in resolution of clinical signs and decreased GAD antibody concentrations.

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Year:  2012        PMID： 22753968      PMCID： PMC3239154     

Source DB:  PubMed          Journal:  Can Vet J        ISSN： 0008-5286            Impact factor:   1.008


  6 in total

1.  Suspected case of stiff-horse syndrome.

Authors:  H Nollet; G Vanderstraeten; B Sustronck; L Van Ham; M Ziegler; P Deprez
Journal:  Vet Rec       Date:  2000-03-04       Impact factor: 2.695

2.  Cerebellar ataxia with anti-glutamic acid decarboxylase antibodies: study of 14 patients.

Authors:  J Honnorat; A Saiz; B Giometto; A Vincent; L Brieva; C de Andres; J Maestre; N Fabien; A Vighetto; R Casamitjana; C Thivolet; B Tavolato; J Antoine; P Trouillas; F Graus
Journal:  Arch Neurol       Date:  2001-02

3.  Gabapentin for the treatment of neuropathic pain in a pregnant horse.

Authors:  Jennifer L Davis; Lysa P Posner; Yvonne Elce
Journal:  J Am Vet Med Assoc       Date:  2007-09-01       Impact factor: 1.936

4.  Spectrum of neurological syndromes associated with glutamic acid decarboxylase antibodies: diagnostic clues for this association.

Authors:  Albert Saiz; Yolanda Blanco; Lidia Sabater; Félix González; Luis Bataller; Roser Casamitjana; Lluis Ramió-Torrentà; Francesc Graus
Journal:  Brain       Date:  2008-08-07       Impact factor: 13.501

5.  Tetanus in the equine species: a retrospective study of 31 cases.

Authors:  G van Galen; C Delguste; C Sandersen; D Verwilghen; S Grulke; H Amory
Journal:  Tijdschr Diergeneeskd       Date:  2008-06-15

6.  Stiff-person syndrome following West Nile fever.

Authors:  Sharon Hassin-Baer; Eilon D Kirson; Lester Shulman; Aron S Buchman; Hanna Bin; Musa Hindiyeh; Lea Markevich; Ella Mendelson
Journal:  Arch Neurol       Date:  2004-06
  6 in total
  2 in total

1.  A case of stiff dog syndrome associated with anti-glutamic acid decarboxylase antibodies.

Authors:  Theresa E Pancotto; John H Rossmeisl
Journal:  J Clin Mov Disord       Date:  2017-05-10

Review 2.  Immune-mediated cerebellar ataxias: from bench to bedside.

Authors:  Hiroshi Mitoma; Mario Manto; Christiane S Hampe
Journal:  Cerebellum Ataxias       Date:  2017-09-21
  2 in total

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