OBJECTIVES/HYPOTHESIS: To evaluate the reliability of the sentinel node (SN) biopsy in early oral squamous cell carcinomas. STUDY DESIGN: Prospective cohort study. METHODS: We conducted a primary prospective study on 53 consecutive patients presenting T1, T2 N0 squamous cell carcinomas of the oral cavity between January 2000 and June 2003. Primary results demonstrated a negative predictive value of 100%. The series was then extended until June 2010, with a total number of 166 successful procedures. RESULTS: The cohort accounted for 118 males and 48 females with a mean age of 56 years. The median follow-up period was 36 months. There were 42 patients (25%) with positive SNs, 14 of them (33%) only harboring micrometastasis. The negative predictive value of the sentinel node biopsy was 95.2%. The SN involvement was strongly correlated with the tumor location (34% of SN+ for the tongue vs. 13% for the floor of mouth, P = .003), tumor stage (18% of SN+ for T1 vs. 40% for T2, P = .002), depth of invasion (median depth for SN+ lesions was 6.5 mm vs. 4 mm for SN- lesions, P = .028), and lymphovascular involvement (P = .002). The false-negative rate of frozen section examination was 42%. CONCLUSIONS: The sentinel node biopsy appears to be an excellent staging method in early oral cancers. This study also provides evidence that routinely undiagnosed micrometastasis may have clinical significance.
OBJECTIVES/HYPOTHESIS: To evaluate the reliability of the sentinel node (SN) biopsy in early oral squamous cell carcinomas. STUDY DESIGN: Prospective cohort study. METHODS: We conducted a primary prospective study on 53 consecutive patients presenting T1, T2 N0 squamous cell carcinomas of the oral cavity between January 2000 and June 2003. Primary results demonstrated a negative predictive value of 100%. The series was then extended until June 2010, with a total number of 166 successful procedures. RESULTS: The cohort accounted for 118 males and 48 females with a mean age of 56 years. The median follow-up period was 36 months. There were 42 patients (25%) with positive SNs, 14 of them (33%) only harboring micrometastasis. The negative predictive value of the sentinel node biopsy was 95.2%. The SN involvement was strongly correlated with the tumor location (34% of SN+ for the tongue vs. 13% for the floor of mouth, P = .003), tumor stage (18% of SN+ for T1 vs. 40% for T2, P = .002), depth of invasion (median depth for SN+ lesions was 6.5 mm vs. 4 mm for SN- lesions, P = .028), and lymphovascular involvement (P = .002). The false-negative rate of frozen section examination was 42%. CONCLUSIONS: The sentinel node biopsy appears to be an excellent staging method in early oral cancers. This study also provides evidence that routinely undiagnosed micrometastasis may have clinical significance.
Authors: Christina Bluemel; Domenico Rubello; Patrick M Colletti; Remco de Bree; Ken Herrmann Journal: Eur J Nucl Med Mol Imaging Date: 2015-04-28 Impact factor: 9.236
Authors: Alhadi Almangush; Antti A Mäkitie; Laura K Mäkinen; Joonas H Kauppila; Matti Pukkila; Jaana Hagström; Jussi Laranne; Ylermi Soini; Luiz Paulo Kowalski; Reidar Grénman; Caj Haglund; Ricardo D Coletta; Tuula Salo; Ilmo Leivo Journal: Virchows Arch Date: 2018-07-23 Impact factor: 4.064
Authors: Inne J Den Toom; Elisabeth Bloemena; Stijn van Weert; K Hakki Karagozoglu; Otto S Hoekstra; Remco de Bree Journal: Eur Arch Otorhinolaryngol Date: 2016-08-25 Impact factor: 2.503