BACKGROUND: Previous studies have indicated a direct effect of μ-opioid receptors on tumor progression or recurrence. An A118G polymorphism in the μ-opioid receptor gene was believed to play an important role in this carcinogenic process. The aim of the present study was to investigate the association between the A118G polymorphism and the risk of esophageal squamous cell carcinoma (ESCC) in a Chinese population. METHOD: The case-control study included 260 cancer patients and 291 controls from a Chinese Han and Chinese TuJia population in Enshi region, China. Genotypes were determined by TaqMan platform. Odds ratios (ORs) and 95 % confidence intervals (CIs) were calculated using multivariate unconditional logistic regression. RESULTS: Compared with the G/G genotype, the A/A genotype exhibited a significantly elevated risk for ESCC (OR = 3.12, 95 % CI [1], 1.11-6.01). A significant interaction between the A118G polymorphism and age, smoking status, and family history of cancer was also found (OR = 2.25, 95 % CI 1.36-4.12; OR = 1.75, 95 % CI 1.23-2.32; OR = 3.14, 95 % CI 1.31-7.28, respectively). CONCLUSION: The A118G polymorphism in the μ-opioid receptor gene might be associated with the risk of ESCC in Chinese population.
BACKGROUND: Previous studies have indicated a direct effect of μ-opioid receptors on tumor progression or recurrence. An A118G polymorphism in the μ-opioid receptor gene was believed to play an important role in this carcinogenic process. The aim of the present study was to investigate the association between the A118G polymorphism and the risk of esophageal squamous cell carcinoma (ESCC) in a Chinese population. METHOD: The case-control study included 260 cancerpatients and 291 controls from a Chinese Han and Chinese TuJia population in Enshi region, China. Genotypes were determined by TaqMan platform. Odds ratios (ORs) and 95 % confidence intervals (CIs) were calculated using multivariate unconditional logistic regression. RESULTS: Compared with the G/G genotype, the A/A genotype exhibited a significantly elevated risk for ESCC (OR = 3.12, 95 % CI [1], 1.11-6.01). A significant interaction between the A118G polymorphism and age, smoking status, and family history of cancer was also found (OR = 2.25, 95 % CI 1.36-4.12; OR = 1.75, 95 % CI 1.23-2.32; OR = 3.14, 95 % CI 1.31-7.28, respectively). CONCLUSION: The A118G polymorphism in the μ-opioid receptor gene might be associated with the risk of ESCC in Chinese population.
Authors: Aristomenis K Exadaktylos; Donal J Buggy; Denis C Moriarty; Edward Mascha; Daniel I Sessler Journal: Anesthesiology Date: 2006-10 Impact factor: 7.892
Authors: Alexander Schultze; Isabel Ben Batalla; Sabine Riethdorf; Michael Bubenheim; Emre Yekebas; Andreas Erbersdobler; Uta Reichelt; Katharina E Effenberger; Thomas Schmidt; Jakob R Izbicki; Carsten Bokemeyer; Klaus Pantel; Walter Fiedler; Sonja Loges Journal: Clin Exp Metastasis Date: 2012-04-08 Impact factor: 5.150
Authors: Kalpna Gupta; Smita Kshirsagar; Liming Chang; Robert Schwartz; Ping-Y Law; Doug Yee; Robert P Hebbel Journal: Cancer Res Date: 2002-08-01 Impact factor: 12.701
Authors: Thomas A Aloia; Bradford J Kim; Yun Shin Segraves-Chun; Juan P Cata; Mark J Truty; Qiuling Shi; Alexander Holmes; Jose M Soliz; Keyuri U Popat; Thomas F Rahlfs; Jeffrey E Lee; Xin Shelley Wang; Jeffrey S Morris; Vijaya N R Gottumukkala; Jean-Nicolas Vauthey Journal: Ann Surg Date: 2017-09 Impact factor: 12.969
Authors: Dylan Zylla; Brett L Gourley; Derek Vang; Scott Jackson; Sonja Boatman; Bruce Lindgren; Michael A Kuskowski; Chap Le; Kalpna Gupta; Pankaj Gupta Journal: Cancer Date: 2013-09-16 Impact factor: 6.860
Authors: Darren M Brenner; Neal E Slatkin; Nancy Stambler; Robert J Israel; Paul H Coluzzi Journal: Support Care Cancer Date: 2021-02-25 Impact factor: 3.603
Authors: James G Connolly; Kay See Tan; Brooke Mastrogiacomo; Joseph Dycoco; Raul Caso; Gregory D Jones; Patrick J McCormick; Francisco Sanchez-Vega; Takeshi Irie; Joseph R Scarpa; Hersh V Gupta; Prasad S Adusumilli; Gaetano Rocco; James M Isbell; Matthew J Bott; Gregory W Fischer; David R Jones; Joshua S Mincer Journal: Br J Anaesth Date: 2021-07 Impact factor: 11.719