Literature DB >> 22750567

Label-free highly sensitive detection of telomerase activity in cancer cell by chemiluminescence imaging.

Changbei Ma1, Kun Xia, Hanchun Chen, Weimin Zeng, Rui Han, Jianhua Tang.   

Abstract

We have developed a new methodology for label-free highly sensitive telomerase activity assay using chemiluminescence imaging. This method can detect the telomerase activity from as little as 10 cultured cancer cells without PCR. Furthermore, telomerase inhibition is shown, demonstrating the potential for screening of telomerase inhibitors as anticancer drug agents.
Copyright © 2012 Elsevier Ltd. All rights reserved.

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Year:  2012        PMID: 22750567     DOI: 10.1016/j.mcp.2012.06.002

Source DB:  PubMed          Journal:  Mol Cell Probes        ISSN: 0890-8508            Impact factor:   2.365


  1 in total

1.  Folate receptor-targeting gold nanoclusters as fluorescence enzyme mimetic nanoprobes for tumor molecular colocalization diagnosis.

Authors:  Dehong Hu; Zonghai Sheng; Shengtao Fang; Yanan Wang; Duyang Gao; Pengfei Zhang; Ping Gong; Yifan Ma; Lintao Cai
Journal:  Theranostics       Date:  2014-01-02       Impact factor: 11.556

  1 in total

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