| Literature DB >> 22750094 |
Ming-Jie Zheng1, Jue Wang, Yuan-Wen Chen, Lu Xu, Dan-Dan Xue, Wei Fu, Yi-Fen Zhang, Qing Du, Yi Zhao, Li-Jun Ling, Qiang Ding, Xiao-An Liu, Xiao-Ming Zha, Wei Zheng, Tian-Song Xia, Shui Wang.
Abstract
Mouse models play an irreplaceable role in the in vivo research of human gastric cancer. In this study, we developed a novel human Gastric tissue-derived Orthotopic and Metastatic (GOM) mouse model of human gastric cancer, in which the human normal gastric tissues were implanted subcutaneously into immunodeficient mice to create a human gastric microenvironment. Then, human gastric cancer cells were injected into the implants. GOM model could mimic the interactions between human gastric microenvironment and human gastric cancer cells, which help exhibit the real characteristics of tumor cells, and finally mimic the clinical-like tumor proliferation and metastases of human beings.Entities:
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Year: 2012 PMID： 22750094 DOI： 10.1016/j.canlet.2012.06.011
Source DB: PubMed Journal: Cancer Lett ISSN： 0304-3835 Impact factor: 8.679