BACKGROUND: Evidence is mounting that magnesium may play a critical role in the development of strokes and the healing process during and after a stroke. Magnesium is an N-methyl-D-aspartate (NMDA) glutamate receptor antagonist that has been shown to be neuroprotective in many preclinical models of ischemic and excitotoxic brain injury. This study was performed to evaluate the intravenous magnesium sulfate effect in clinical improvement of patients with acute ischemic stroke. METHODS:One hundred and seven patients with acute ischemic stroke signs and symptoms lasting less than 12 hours were included in the study and were divided into two groups, 55 patients received4 g of MgSO(4) over 15 minutes and then 16 g over the next 24 hours, and 52 patients were received matching placebo. The study primary end point was stroke related neurologic deficit evaluation by the national institute of stroke scale (NIHSS). RESULTS: Patients receiving MgSO(4) showed significant recovery compared with the group of patients receiving placebo. CONCLUSION: This study suggests that magnesium sulfate can be used as a safe and useful neuroprotective agent in acute ischemic stroke and lacunar stroke patients may represent a relevant and practical target population for agents with biological activity in white matter.
RCT Entities:
BACKGROUND: Evidence is mounting that magnesium may play a critical role in the development of strokes and the healing process during and after a stroke. Magnesium is an N-methyl-D-aspartate (NMDA) glutamate receptor antagonist that has been shown to be neuroprotective in many preclinical models of ischemic and excitotoxic brain injury. This study was performed to evaluate the intravenous magnesium sulfate effect in clinical improvement of patients with acute ischemic stroke. METHODS: One hundred and seven patients with acute ischemic stroke signs and symptoms lasting less than 12 hours were included in the study and were divided into two groups, 55 patients received 4 g of MgSO(4) over 15 minutes and then 16 g over the next 24 hours, and 52 patients were received matching placebo. The study primary end point was stroke related neurologic deficit evaluation by the national institute of stroke scale (NIHSS). RESULTS:Patients receiving MgSO(4) showed significant recovery compared with the group of patients receiving placebo. CONCLUSION: This study suggests that magnesium sulfate can be used as a safe and useful neuroprotective agent in acute ischemic stroke and lacunar strokepatients may represent a relevant and practical target population for agents with biological activity in white matter.
Authors: Sherief Ghozy; Abdullah Reda; Joseph Varney; Ahmed Sallam Elhawary; Jaffer Shah; Kimberly Murry; Mohamed Gomaa Sobeeh; Sandeep S Nayak; Ahmed Y Azzam; Waleed Brinjikji; Ramanathan Kadirvel; David F Kallmes Journal: Front Neurol Date: 2022-05-31 Impact factor: 4.086
Authors: Joseph P Mathew; William D White; David B Schinderle; Mihai V Podgoreanu; Miles Berger; Carmelo A Milano; Daniel T Laskowitz; Mark Stafford-Smith; James A Blumenthal; Mark F Newman Journal: Stroke Date: 2013-10-08 Impact factor: 7.914
Authors: Morgan A Clond; Bong-Seop Lee; Jeffrey J Yu; Matthew B Singer; Takayuki Amano; Alexander W Lamb; Doniel Drazin; Babak Kateb; Eric J Ley; John S Yu Journal: PLoS One Date: 2013-04-24 Impact factor: 3.240
Authors: Abbas Jarrahi; Molly Braun; Meenakshi Ahluwalia; Rohan V Gupta; Michael Wilson; Stephanie Munie; Pankaj Ahluwalia; John R Vender; Fernando L Vale; Krishnan M Dhandapani; Kumar Vaibhav Journal: Biomedicines Date: 2020-09-29