OBJECTIVES: To determine the association between the nuclear respiratory factor 2 (NRF-2) polymorphisms and elite athletic performance. DESIGN: We compared the genotype and allele frequencies of the NRF-2 A/C (rs12594956), NRF-2 A/G (rs7181866), and NRF-2 C/T (rs8031031) polymorphisms between world-class endurance athletes (n=89), elite power-oriented athletes (n=38), and non-athletic controls (n=110) of the same Caucasian (Spanish) origin. METHODS: Genomic DNA was extracted from peripheral EDTA-treated, anti-coagulated blood using a standard protocol. Genotyping was performed using polymerase chain reaction (PCR). RESULTS: The frequency of the AA genotype of the NRF-2 A/C (rs12594956) polymorphism was significantly higher in endurance athletes compared with power athletes (P<0.01) and controls (P<0.01) (48% vs. 13% and 21%, respectively). The likelihood of having the AA (rs12594956) genotype was higher in elite endurance athletes compared with controls [odds ratio (OR): 3.536, 95% confidence interval (CI): 1.903-6.571] and elite power athletes (OR: 6.170, 95%CI: 2.206-17.253). CONCLUSIONS: Our results suggest that the NRF-2 A/C polymorphism might belong to a growing group of polymorphisms associated with endurance performance at the elite level. However, it is important to replicate these findings in other groups of elite athletes using larger sample sizes.
OBJECTIVES: To determine the association between the nuclear respiratory factor 2 (NRF-2) polymorphisms and elite athletic performance. DESIGN: We compared the genotype and allele frequencies of the NRF-2 A/C (rs12594956), NRF-2 A/G (rs7181866), and NRF-2 C/T (rs8031031) polymorphisms between world-class endurance athletes (n=89), elite power-oriented athletes (n=38), and non-athletic controls (n=110) of the same Caucasian (Spanish) origin. METHODS: Genomic DNA was extracted from peripheral EDTA-treated, anti-coagulated blood using a standard protocol. Genotyping was performed using polymerase chain reaction (PCR). RESULTS: The frequency of the AA genotype of the NRF-2 A/C (rs12594956) polymorphism was significantly higher in endurance athletes compared with power athletes (P<0.01) and controls (P<0.01) (48% vs. 13% and 21%, respectively). The likelihood of having the AA (rs12594956) genotype was higher in elite endurance athletes compared with controls [odds ratio (OR): 3.536, 95% confidence interval (CI): 1.903-6.571] and elite power athletes (OR: 6.170, 95%CI: 2.206-17.253). CONCLUSIONS: Our results suggest that the NRF-2 A/C polymorphism might belong to a growing group of polymorphisms associated with endurance performance at the elite level. However, it is important to replicate these findings in other groups of elite athletes using larger sample sizes.
Authors: Magdalena Dzitkowska-Zabielska; Aleksandra Bojarczuk; Małgorzata Borczyk; Marcin Piechota; Michał Korostyński; Jakub Grzegorz Adamczyk; Grzegorz Trybek; Myosotis Massidda; Paweł Cięszczyk Journal: Genes (Basel) Date: 2022-05-12 Impact factor: 4.141
Authors: Ii Ahmetov; Na Kulemin; Dv Popov; Va Naumov; Eb Akimov; Yr Bravy; Es Egorova; Aa Galeeva; Ev Generozov; Es Kostryukova; Ak Larin; Lj Mustafina; Ea Ospanova; Av Pavlenko; Lm Starnes; P Żmijewski; Dg Alexeev; Ol Vinogradova; Vm Govorun Journal: Biol Sport Date: 2014-10-21 Impact factor: 2.806
Authors: N Eynon; L R Griffiths; N R Harvey; S Voisin; R A Lea; X Yan; M C Benton; I D Papadimitriou; M Jacques; L M Haupt; K J Ashton Journal: Sci Rep Date: 2020-07-06 Impact factor: 4.379
Authors: Sarah Voisin; Pawel Cieszczyk; Vladimir P Pushkarev; Dmitry A Dyatlov; Boris F Vashlyayev; Vladimir A Shumaylov; Agnieszka Maciejewska-Karlowska; Marek Sawczuk; Lidia Skuza; Zbigniew Jastrzebski; David J Bishop; Nir Eynon Journal: BMC Genomics Date: 2014-05-18 Impact factor: 3.969