| Literature DB >> 22749420 |
Finn K Hansen1, Mehdi Khankischpur, Ibrahim Tolaymat, Renata Mesaros, Gerd Dannhardt, Detlef Geffken.
Abstract
A series of 3-hydroxybenzo[b]thiophene-2-carboxylic acid derivatives has been prepared and subsequently evaluated with regards to the inhibition of 5-LOX/COX. Structure optimization furnished derivatives with promising in vitro activity as dual 5-LOX/COX inhibitors with submicromolar IC(50) values for inhibition of 5-LOX and COX-1, respectively.Entities:
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Year: 2012 PMID： 22749420 DOI： 10.1016/j.bmcl.2012.06.012
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823