Literature DB >> 22749068

Decreased DNA methylation in acute myeloid leukemia patients with DNMT3A mutations and prognostic implications of DNA methylation.

Hana Hájková1, Jana Marková, Cedrik Haškovec, Iveta Sárová, Ota Fuchs, Arnošt Kostečka, Petr Cetkovský, Kyra Michalová, Jiří Schwarz.   

Abstract

We examined 79 acute myeloid leukemia (AML) patients for DNA methylation of 12 tumor suppressor genes (TSG) and 24 homeobox domain (Hox) genes, and additionally for mutations in DNMT3A gene. We observed lower levels of DNA methylation (P<0.0001) as well as smaller numbers of concurrently hypermethylated genes (P<0.0001) in patients with DNMT3A mutations. Our study of the impact of DNA methylation on prognosis in intermediate and high risk AML patients revealed a relation between higher DNA methylation and better patients' outcome. Lower DNA methylation was linked with higher relapse rates and an inferior overall survival.
Copyright © 2012 Elsevier Ltd. All rights reserved.

Entities:  

Mesh：

Substances：

Year:  2012        PMID： 22749068     DOI： 10.1016/j.leukres.2012.05.012

Source DB:  PubMed          Journal:  Leuk Res        ISSN： 0145-2126            Impact factor:   3.156


  24 in total

1.  Mutant WT1 is associated with DNA hypermethylation of PRC2 targets in AML and responds to EZH2 inhibition.

Authors:  Subarna Sinha; Daniel Thomas; Linda Yu; Andrew J Gentles; Namyoung Jung; M Ryan Corces-Zimmerman; Steven M Chan; Andreas Reinisch; Andrew P Feinberg; David L Dill; Ravindra Majeti
Journal:  Blood       Date:  2014-11-14       Impact factor: 22.113

Review 2.  Mutant DNA methylation regulators endow hematopoietic stem cells with the preleukemic stem cell property, a requisite of leukemia initiation and relapse.

Authors:  Yuting Tan; Han Liu; Saijuan Chen
Journal:  Front Med       Date:  2015-12       Impact factor: 4.592

3.  Differential methylation in CN-AML preferentially targets non-CGI regions and is dictated by DNMT3A mutational status and associated with predominant hypomethylation of HOX genes.

Authors:  Ying Qu; Andreas Lennartsson; Verena I Gaidzik; Stefan Deneberg; Mohsen Karimi; Sofia Bengtzén; Martin Höglund; Lars Bullinger; Konstanze Döhner; Sören Lehmann
Journal:  Epigenetics       Date:  2014-05-27       Impact factor: 4.528

Review 4.  DNMT3A in haematological malignancies.

Authors:  Liubin Yang; Rachel Rau; Margaret A Goodell
Journal:  Nat Rev Cancer       Date:  2015-02-19       Impact factor: 60.716

5.  Exposure to low-dose (56)Fe-ion radiation induces long-term epigenetic alterations in mouse bone marrow hematopoietic progenitor and stem cells.

Authors:  Isabelle R Miousse; Lijian Shao; Igor Koturbash; Jianhui Chang; Wei Feng; Yingying Wang; Antiño R Allen; Jennifer Turner; Blair Stewart; Jacob Raber; Daohong Zhou
Journal:  Radiat Res       Date:  2014-06-24       Impact factor: 2.841

6.  Let-7a-3 hypomethylation is associated with favorable/intermediate karyotypes but not with survival in acute myeloid leukemia.

Authors:  Xiao-Wen Zhu; Dong-Ming Yao; De-Hong Wu; Xiang-Mei Wen; Jing Yang; Hong Guo; Lei Yang; Zhao-Qun Deng; Ying-Ying Zhang; Wei Qian; Jiang Lin; Jun Qian
Journal:  Tumour Biol       Date:  2015-07-31

Review 7.  Molecular-based classification of acute myeloid leukemia and its role in directing rational therapy: personalized medicine for profoundly promiscuous proliferations.

Authors:  Gerald B W Wertheim; Elizabeth Hexner; Adam Bagg
Journal:  Mol Diagn Ther       Date:  2012-12       Impact factor: 4.074

8.  The Impact of DNMT3A Status on NPM1 MRD Predictive Value and Survival in Elderly AML Patients Treated Intensively.

Authors:  Heiblig Maël; Duployez Nicolas; Marceau Alice; Lebon Delphine; Goursaud Laure; Plantier Isabelle; Stalnikiewich Laure; Cambier Nathalie; Balsat Marie; Fossard Gaëlle; Labussière-Wallet Hélène; Barraco Fiorenza; Ducastelle-Lepretre Sophie; Sujobert Pierre; Huet Sarah; Hayette Sandrine; Ghesquières Hervé; Thomas Xavier; Preudhomme Claude
Journal:  Cancers (Basel)       Date:  2021-04-29       Impact factor: 6.639

9.  Study on the Immune Escape Mechanism of Acute Myeloid Leukemia With DNMT3A Mutation.

Authors:  Yimei Que; Huimin Li; Liman Lin; Xiaojian Zhu; Min Xiao; Ying Wang; Li Zhu; Dengju Li
Journal:  Front Immunol       Date:  2021-05-20       Impact factor: 7.561

10.  Adverse Impact of DNA Methylation Regulatory Gene Mutations on the Prognosis of AML Patients in the 2017 ELN Favorable Risk Group, Particularly Those Defined by NPM1 Mutation.

Authors:  James Yu; Jingxin Sun; Yuan Du; Rushang Patel; Juan Carlos Varela; Shahram Mori; Chung-Che Chang
Journal:  Diagnostics (Basel)       Date:  2021-05-29
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.