Literature DB >> 22748822

Expression of RUNX1 isoforms and its target gene BLK in childhood acute lymphoblastic leukemia.

Oreth Montero-Ruíz1, Miguel Angel Alcántara-Ortigoza, Miguel Betancourt, Rocío Juárez-Velázquez, Humberto González-Márquez, Patricia Pérez-Vera.   

Abstract

Bone marrow samples from children with acute lymphoblastic leukemia were analyzed for the expression of RUNX1a/b/c isoforms. Obtained patterns were associated with genetic abnormalities and the expression of the RUNX1 regulated gene BLK. RUNX1c was present in all patients, but the expected over-expression of RUNX1a was not observed. Over-expression of total RUNT domain isoforms was detected in patients with extra RUNX1 copies, and unexpectedly, in those with t(4;11). Only expression of the total RUNT domain-containing isoforms and BLK presented positive correlation. Results suggest a more complex role of RUNX1 in leukemogenesis than the proposed antagonism between the isoforms.
Copyright © 2012 Elsevier Ltd. All rights reserved.

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Year:  2012        PMID： 22748822     DOI： 10.1016/j.leukres.2012.05.019

Source DB:  PubMed          Journal:  Leuk Res        ISSN： 0145-2126            Impact factor:   3.156


  10 in total

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4.  LMO2 Oncoprotein Stability in T-Cell Leukemia Requires Direct LDB1 Binding.

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8.  Prognostic significance of BLK expression in R-CHOP treated diffuse large B-cell lymphoma.

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9.  RUNX1 is a key target in t(4;11) leukemias that contributes to gene activation through an AF4-MLL complex interaction.

Authors:  Adam C Wilkinson; Erica Ballabio; Huimin Geng; Phillip North; Marta Tapia; Jon Kerry; Debabrata Biswas; Robert G Roeder; C David Allis; Ari Melnick; Marella F T R de Bruijn; Thomas A Milne
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  10 in total

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