OBJECTIVE: Both brain and body temperature rise after stroke but the cause of each is uncertain. We investigated the relationship between circulating markers of inflammation with brain and body temperature after stroke. METHODS: We recruited patients with acute ischemic stroke and measured brain temperature at hospital admission and 5 days after stroke with multivoxel magnetic resonance spectroscopic imaging in normal brain and the acute ischemic lesion (defined by diffusion-weighted imaging [DWI]). We measured body temperature with digital aural thermometers 4-hourly and drew blood daily to measure interleukin-6, C-reactive protein, and fibrinogen, for 5 days after stroke. RESULTS: In 44 stroke patients, the mean temperature in DWI-ischemic brain soon after admission was 38.4° C (95% confidence interval [CI] 38.2-38.6), in DWI-normal brain was 37.7° C (95% CI 37.6-37.7), and mean body temperature was 36.6° C (95% CI 36.3-37.0). Higher mean levels of interleukin-6, C-reactive protein, and fibrinogen were associated with higher temperature in DWI-normal brain at admission and 5 days, and higher overall mean body temperature, but only with higher temperature in DWI-ischemic brain on admission. CONCLUSIONS: Systemic inflammation after stroke is associated with elevated temperature in normal brain and the body but not with later ischemic brain temperature. Elevated brain temperature is a potential mechanism for the poorer outcome observed in stroke patients with higher levels of circulating inflammatory markers.
OBJECTIVE: Both brain and body temperature rise after stroke but the cause of each is uncertain. We investigated the relationship between circulating markers of inflammation with brain and body temperature after stroke. METHODS: We recruited patients with acute ischemic stroke and measured brain temperature at hospital admission and 5 days after stroke with multivoxel magnetic resonance spectroscopic imaging in normal brain and the acute ischemic lesion (defined by diffusion-weighted imaging [DWI]). We measured body temperature with digital aural thermometers 4-hourly and drew blood daily to measure interleukin-6, C-reactive protein, and fibrinogen, for 5 days after stroke. RESULTS: In 44 stroke patients, the mean temperature in DWI-ischemic brain soon after admission was 38.4° C (95% confidence interval [CI] 38.2-38.6), in DWI-normal brain was 37.7° C (95% CI 37.6-37.7), and mean body temperature was 36.6° C (95% CI 36.3-37.0). Higher mean levels of interleukin-6, C-reactive protein, and fibrinogen were associated with higher temperature in DWI-normal brain at admission and 5 days, and higher overall mean body temperature, but only with higher temperature in DWI-ischemic brain on admission. CONCLUSIONS: Systemic inflammation after stroke is associated with elevated temperature in normal brain and the body but not with later ischemic brain temperature. Elevated brain temperature is a potential mechanism for the poorer outcome observed in stroke patients with higher levels of circulating inflammatory markers.
Authors: T Brott; H P Adams; C P Olinger; J R Marler; W G Barsan; J Biller; J Spilker; R Holleran; R Eberle; V Hertzberg Journal: Stroke Date: 1989-07 Impact factor: 7.914
Authors: Ian Marshall; Bartosz Karaszewski; Joanna M Wardlaw; Vera Cvoro; Karolina Wartolowska; Paul A Armitage; Trevor Carpenter; Mark E Bastin; Andrew Farrall; Kristin Haga Journal: Magn Reson Imaging Date: 2006-04-27 Impact factor: 2.546
Authors: William Whiteley; Caroline Jackson; Steff Lewis; Gordon Lowe; Ann Rumley; Peter Sandercock; Joanna Wardlaw; Martin Dennis; Cathie Sudlow Journal: PLoS Med Date: 2009-09-08 Impact factor: 11.069
Authors: S Dehkharghani; M Bowen; D C Haussen; T Gleason; A Prater; Q Cai; J Kang; R G Nogueira Journal: AJNR Am J Neuroradiol Date: 2016-10-06 Impact factor: 3.825
Authors: Bartosz Karaszewski; Trevor K Carpenter; Ralph G R Thomas; Paul A Armitage; Georgina Katherine S Lymer; Ian Marshall; Martin S Dennis; Joanna M Wardlaw Journal: J Cereb Blood Flow Metab Date: 2013-04-10 Impact factor: 6.200
Authors: Michael J Thrippleton; Jehill Parikh; Bridget A Harris; Steven J Hammer; Scott I K Semple; Peter J D Andrews; Joanna M Wardlaw; Ian Marshall Journal: NMR Biomed Date: 2013-11-24 Impact factor: 4.044