Literature DB >> 22744258

Adverse drug reaction: rosuvastatin as a cause for ischaemic colitis in a 64-year-old woman.

Jackie Tan1, Casper Francois Pretorius, Paul Vincent Flanagan, Antonio Pais.   

Abstract

Rosuvastatin (Crestor, AstraZeneca) is a commonly used drug for managing hypercholesterolaemia. It is a very safe medication with mostly acceptable side effects. Rare but serious side effects are not well known. A 64-year-old woman presented with bloody diarrhoea after starting rosuvastatin for hypercholesterolaemia. Stool microscopy and culture ruled out infective causes. Abdominal CT scan revealed normal calibre celiac axis and superior mesenteric artery. Colonoscopic biopsy revealed ischaemic colitis as the final histological diagnosis. The patient is in complete remission after ceasing the medication. Rosuvastatin causing ischaemic colitis should be considered a rare but serious adverse drug reaction.

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Year:  2012        PMID: 22744258      PMCID: PMC3448351          DOI: 10.1136/bcr.11.2011.5270

Source DB:  PubMed          Journal:  BMJ Case Rep        ISSN: 1757-790X


  5 in total

1.  Ischemic colitis: patterns and prognosis.

Authors:  W E Longo; G H Ballantyne; R J Gusberg
Journal:  Dis Colon Rectum       Date:  1992-08       Impact factor: 4.585

2.  Cardiovascular event reduction and adverse events among subjects attaining low-density lipoprotein cholesterol <50 mg/dl with rosuvastatin. The JUPITER trial (Justification for the Use of Statins in Prevention: an Intervention Trial Evaluating Rosuvastatin).

Authors:  Judith Hsia; Jean G MacFadyen; John Monyak; Paul M Ridker
Journal:  J Am Coll Cardiol       Date:  2011-04-19       Impact factor: 24.094

3.  Effect of very high-intensity statin therapy on regression of coronary atherosclerosis: the ASTEROID trial.

Authors:  Steven E Nissen; Stephen J Nicholls; Ilke Sipahi; Peter Libby; Joel S Raichlen; Christie M Ballantyne; Jean Davignon; Raimund Erbel; Jean Charles Fruchart; Jean-Claude Tardif; Paul Schoenhagen; Tim Crowe; Valerie Cain; Kathy Wolski; Marlene Goormastic; E Murat Tuzcu
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Review 4.  An overview of the extra-lipid effects of rosuvastatin.

Authors:  Michael S Kostapanos; Haralampos J Milionis; Moses S Elisaf
Journal:  J Cardiovasc Pharmacol Ther       Date:  2008-05-06       Impact factor: 2.457

Review 5.  Rosuvastatin-associated adverse effects and drug-drug interactions in the clinical setting of dyslipidemia.

Authors:  Michael S Kostapanos; Haralampos J Milionis; Moses S Elisaf
Journal:  Am J Cardiovasc Drugs       Date:  2010       Impact factor: 3.571

  5 in total
  3 in total

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2.  Adverse reactions to dietary supplements containing red yeast rice: assessment of cases from the Italian surveillance system.

Authors:  Gabriela Mazzanti; Paola Angela Moro; Emanuel Raschi; Roberto Da Cas; Francesca Menniti-Ippolito
Journal:  Br J Clin Pharmacol       Date:  2017-01-19       Impact factor: 4.335

3.  Atorvastatin attenuates TNBS-induced rat colitis: the involvement of the TLR4/NF-kB signaling pathway.

Authors:  Amir Rashidian; Ahad Muhammadnejad; Ahmad-Reza Dehpour; Shahram Ejtemai Mehr; Maziar Mohammad Akhavan; Reza Shirkoohi; Mohsen Chamanara; Seyyedeh-Elaheh Mousavi; Seyed-Mahdi Rezayat
Journal:  Inflammopharmacology       Date:  2016-04-02       Impact factor: 4.473

  3 in total

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