| Literature DB >> 22743615 |
Han Chen1, Josephine Mun Yee Ko, Victor Chun Lam Wong, Marko Hyytiainen, Jorma Keski-Oja, Daniel Chua, John M Nicholls, Florence Man Fung Cheung, Anne Wing Mui Lee, Dora Lai-Wan Kwong, Pui Man Chiu, Eugene R Zabarovsky, Sai Wah Tsao, Qian Tao, Rebecca Kan, Stephen Ho Kin Chan, Eric J Stanbridge, Maria Li Lung.
Abstract
This study identified LTBP-2 as a pleiotropic tumor suppressor in nasopharyngeal carcinoma, which safeguards against critical malignant behaviors of tumor cells. LTBP-2 expression was significantly decreased or lost in up to 100% of NPC cell lines (7/7) and 80% of biopsies (24/30). Promoter hypermethylation was found to be involved in LTBP-2 silencing. Using a tetracycline-regulated inducible expression system, we unveiled functional roles of LTBP-2 in suppressing colony formation, anchorage-independent growth, cell migration, angiogenesis, VEGF secretion, and tumorigenicity. Three-dimensional culture studies suggested the involvement of LTBP-2 in maintenance of tumor cell dormancy in a growth factor favorable microenvironment.Entities:
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Year: 2012 PMID： 22743615 DOI： 10.1016/j.canlet.2012.06.005
Source DB: PubMed Journal: Cancer Lett ISSN： 0304-3835 Impact factor: 8.679