BACKGROUND: Valid prognostic factors for early identification of a complicated course after orthotopic liver transplantation from deceased donors are rare. The aim of this study was to investigate the prognostic value of different cell death biomarkers and inflammatory markers in patients after orthotopic liver transplantation from deceased donors. METHODS: In total, 100 patients were evaluated for short-term complications within 10 days after orthotopic liver transplantation from deceased donors. Blood samples were collected before surgery, immediately after the end of the surgical procedure, and 1 day and 3, 5, and 7 days later. Plasma levels of total keratin 18, keratin 18 fragments, interleukin 6, tumor necrosis factor α, and soluble intercellular adhesion molecule 1 were measured. RESULTS: Total keratin 18 was demonstrated to be favorable in its prognostic value for early identification of a complicated course in comparison to routine markers of liver impairment (e.g., aspartate aminotransferase, alanine aminotransferase, lactate dehydrogenase). In contrast, inflammation markers (e.g., interleukin 6, tumor necrosis factor α and soluble intercellular adhesion molecule 1) were unsuitable for predicting early complications after liver transplantation from deceased donors. CONCLUSIONS: For early identification of patients at high risk for complications, the implementation of total keratin 18 measurements in routine diagnostics after orthotopic liver transplantation from deceased donors should be taken into consideration.
BACKGROUND: Valid prognostic factors for early identification of a complicated course after orthotopic liver transplantation from deceased donors are rare. The aim of this study was to investigate the prognostic value of different cell death biomarkers and inflammatory markers in patients after orthotopic liver transplantation from deceased donors. METHODS: In total, 100 patients were evaluated for short-term complications within 10 days after orthotopic liver transplantation from deceased donors. Blood samples were collected before surgery, immediately after the end of the surgical procedure, and 1 day and 3, 5, and 7 days later. Plasma levels of total keratin 18, keratin 18 fragments, interleukin 6, tumor necrosis factor α, and soluble intercellular adhesion molecule 1 were measured. RESULTS: Total keratin 18 was demonstrated to be favorable in its prognostic value for early identification of a complicated course in comparison to routine markers of liver impairment (e.g., aspartate aminotransferase, alanine aminotransferase, lactate dehydrogenase). In contrast, inflammation markers (e.g., interleukin 6, tumor necrosis factor α and soluble intercellular adhesion molecule 1) were unsuitable for predicting early complications after liver transplantation from deceased donors. CONCLUSIONS: For early identification of patients at high risk for complications, the implementation of total keratin 18 measurements in routine diagnostics after orthotopic liver transplantation from deceased donors should be taken into consideration.
Authors: Min Yang; Daniel J Antoine; James L Weemhoff; Rosalind E Jenkins; Anwar Farhood; B Kevin Park; Hartmut Jaeschke Journal: Liver Transpl Date: 2014-11 Impact factor: 5.799
Authors: Sebastian O Decker; Albert Krüger; Henryk Wilk; Florian Uhle; Thomas Bruckner; Stefan Hofer; Markus A Weigand; Thorsten Brenner; Aleksandar R Zivkovic Journal: Biomolecules Date: 2022-07-15
Authors: Thorsten Brenner; Thomas H Fleming; David Spranz; Peter Schemmer; Thomas Bruckner; Florian Uhle; Eike O Martin; Markus A Weigand; Stefan Hofer Journal: Mediators Inflamm Date: 2013-05-22 Impact factor: 4.711
Authors: Leonardo Lorente; Sergio T Rodriguez; Pablo Sanz; Antonia Pérez-Cejas; Javier Padilla; Dácil Díaz; Antonio González; María M Martín; Alejandro Jiménez; Manuel A Barrera Journal: Int J Mol Sci Date: 2016-09-09 Impact factor: 5.923
Authors: Philipp Houben; Ralph Hohenberger; Kenya Yamanaka; Markus W Büchler; Peter Schemmer Journal: Ann Transplant Date: 2018-07-13 Impact factor: 1.530