Literature DB >> 22743353

Electrochemically driven drug metabolism via cytochrome P450 2C9 isozyme microsomes with cytochrome P450 reductase and indium tin oxide nanoparticle composites.

Xuan Xu1, Wei Wei, Minghe Huang, Li Yao, Songqin Liu.   

Abstract

We describe herein an electrochemically driven drug metabolism strategy based on nanocomposites that integrate cyt P450 2C9 (CYP2C9) isozyme microsomes with cyt P450 reductase (CPR), indium tin oxide (ITO) nanoparticles and chitosan (CS). This novel bioelectronic system enables monitoring of the drug metabolism and enzyme inhibition.

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Year:  2012        PMID： 22743353     DOI： 10.1039/c2cc33575a

Source DB:  PubMed          Journal:  Chem Commun (Camb)        ISSN： 1359-7345            Impact factor:   6.222


  2 in total

1.  The use of immobilized cytochrome P4502C9 in PMMA-based plug flow bioreactors for the production of drug metabolites.

Authors:  Lance A Wollenberg; Jarod L Kabulski; Matthew J Powell; Jifeng Chen; Darcy R Flora; Timothy S Tracy; Peter M Gannett
Journal:  Appl Biochem Biotechnol       Date:  2013-10-30       Impact factor: 2.926

Review 2.  Recent Advances in Electrochemical Biosensors Based on Enzyme Inhibition for Clinical and Pharmaceutical Applications.

Authors:  Loubna El Harrad; Ilhame Bourais; Hasna Mohammadi; Aziz Amine
Journal:  Sensors (Basel)       Date:  2018-01-09       Impact factor: 3.576
  2 in total

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