Preconditioning with hypercapnic acidosis: hope for the ischemic brain.

Acidosis is an important stress factor triggering cell death under ischemic stress. Accordingly, short acidic pretreatment, i.e. acidic preconditioning, has been used to protect heart and liver. Now the beneficial effect of pretreatment with hypercapnic acidosis against ischemia/reperfusion-induced cell death has also been shown for the brain. The possible underlying cellular mechanisms of the protection as well as role of acidic and hypercapnic sensing are briefly discussed.