OBJECTIVE: To describe our institutional experience with deep-brain stimulation (DBS) used in the treatment of aggressive and disruptive behavior refractory to conservative treatment. METHODS: With stereotactic methodology and under general anesthesia, seven patients (from 2002 to 2010) were given DBS in the posterior hypothalamic region, bilaterally, and with the aid of intraoperative microrecording. RESULTS: Six of seven patients presented a clear reduction in the aggression and disruptive bouts, with subsequent simplification of familiar management. CONCLUSIONS: DBS of the posterior hypothalamic region could be an effective treatment for patients affected by mental retardation in whom disruptive and drug-refractory aggressive behavior coexists. Although several experimental data are available on this target, further studies are necessary to confirm the long-term efficacy and safety of this procedure.
OBJECTIVE: To describe our institutional experience with deep-brain stimulation (DBS) used in the treatment of aggressive and disruptive behavior refractory to conservative treatment. METHODS: With stereotactic methodology and under general anesthesia, seven patients (from 2002 to 2010) were given DBS in the posterior hypothalamic region, bilaterally, and with the aid of intraoperative microrecording. RESULTS: Six of seven patients presented a clear reduction in the aggression and disruptive bouts, with subsequent simplification of familiar management. CONCLUSIONS: DBS of the posterior hypothalamic region could be an effective treatment for patients affected by mental retardation in whom disruptive and drug-refractory aggressive behavior coexists. Although several experimental data are available on this target, further studies are necessary to confirm the long-term efficacy and safety of this procedure.
Authors: Johannes Fuss; Matthias K Auer; Sarah V Biedermann; Peer Briken; Werner Hacke Journal: J Psychiatry Neurosci Date: 2015-11 Impact factor: 6.186
Authors: Flavia Venetucci Gouveia; Clement Hamani; Erich Talamoni Fonoff; Helena Brentani; Eduardo Joaquim Lopes Alho; Rosa Magaly Campêlo Borba de Morais; Aline Luz de Souza; Sérgio Paulo Rigonatti; Raquel C R Martinez Journal: Neurosurgery Date: 2019-07-01 Impact factor: 4.654
Authors: Volker A Coenen; Máté D Döbrössy; Shi Jia Teo; Johanna Wessolleck; Bastian E A Sajonz; Peter C Reinacher; Annette Thierauf-Emberger; Björn Spittau; Jochen Leupold; Dominik von Elverfeldt; Thomas E Schlaepfer; Marco Reisert Journal: Brain Struct Funct Date: 2021-09-05 Impact factor: 3.270