| Literature DB >> 22743086 |
Rossella Fioravanti1, Ignacio Celestino, Roberta Costi, Giuliana Cuzzucoli Crucitti, Luca Pescatori, Leonardo Mattiello, Ettore Novellino, Paola Checconi, Anna Teresa Palamara, Lucia Nencioni, Roberto Di Santo.
Abstract
A set of polyphenol compounds was synthesized and assayed for their ability in inhibiting influenza A virus replication. A sub-set of them showed low toxicity. The best compounds within this sub-set were 4 and 6g, which inhibited the viral replication in a dose-dependent manner. The antiviral activity of these molecules was demonstrated to be caused by their interference with intracellular pathways exploited for viral replication: (1) MAP kinases controlling nuclear-cytoplasmic traffic of viral ribonucleoprotein complex; (2) redox-sensitive pathways, involved in maturation of viral hemagglutinin protein.Entities:
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Year: 2012 PMID： 22743086 DOI： 10.1016/j.bmc.2012.05.062
Source DB: PubMed Journal: Bioorg Med Chem ISSN： 0968-0896 Impact factor: 3.641