Literature DB >> 22742419

The Nrf2-ARE pathway: a valuable therapeutic target for the treatment of neurodegenerative diseases.

Gururaj Joshi1, Jeffrey A Johnson.   

Abstract

Modulation of NF-E2 related factor 2 (Nrf2) has been shown in several neurodegenerative disorders. The overexpression of Nrf2 has become a potential therapeutic avenue for various neurodegenerative disorders such as Parkinson, Amyotrophic lateral sclerosis, and Alzheimer's disease. The expression of phase II detoxification enzymes is governed by the cis-acting regulatory element known as antioxidant response element (ARE). The transcription factor Nrf2 binds to ARE thereby transcribing multitude of antioxidant genes. Keap1, a culin 3-based E3 ligase that targets Nrf2 for degradation, sequesters Nrf2 in cytoplasm. Disruption of Keap1-Nrf2 interaction or genetic overexpression of Nrf2 can increase the endogenous antioxidant capacity of the brain thereby rendering protection against oxidative stress in neurodegenerative disorders. This review primarily focuses on recent patents that target Nrf2 overexpression as a promising therapeutic strategy for the treatment of neurodegenerative disorders.

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Year:  2012        PMID： 22742419      PMCID： PMC3625035          DOI： 10.2174/157488912803252023

Source DB:  PubMed          Journal:  Recent Pat CNS Drug Discov        ISSN： 1574-8898


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  76 in total

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