| Literature DB >> 2274113 |
Abstract
Peripheral administrations of TFMPP (0.2- 1 mg/kg) or MCPP (1 mg/kg) facilitated lordosis behavior in female rats treated with estradiol benzoate, and had no effects in females primed with estradiol benzoate and progesterone. In contrast, TFMPP (1 mg/kg) and MCPP (1 mg/kg) inhibited copulatory behavior in male rats. It is concluded that there are sex differences in the effects of TFMPP and MCPP on copulatory behavior in the rat. Moreover, it is suggested that the effects of these drugs on copulatory behavior may be mediated by activation of 5-HT1B and/or 5-HT1C receptors, or by blockade of activity at 5-HT3 receptors.Entities:
Mesh：
Substances：
Year: 1990 PMID： 2274113 DOI： 10.1016/0028-3908(90)90133-c
Source DB: PubMed Journal: Neuropharmacology ISSN： 0028-3908 Impact factor: 5.250